Temporal integration of short-duration pulse trains in cochlear implant listeners: Psychophysical and electrophysiological measurements

• Published in: Hearing research Vol. 403; p. 108176
• Main Authors: Macherey, Olivier, Stahl, Pierre, Intartaglia, Bastien, Meunier, Sabine, Roman, Stéphane, Schön, Daniele
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2021; Elsevier
• Subjects: Auditory Threshold; Cochlear implant fitting; Cochlear Implantation; Cochlear Implants; Electric Stimulation; Electrically-evoked auditory brainstem response; Engineering Sciences; Evoked Potentials, Auditory, Brain Stem; Heart Rate; Humans; Neural facilitation; Objective measures; Physics; Temporal integration; Objective measures; Neural facilitation; Temporal integration; Electrically-evoked auditory brainstem response; Cochlear implant fitting; electrically-evoked auditory brainstem response; temporal integration; objective
• ISSN: 0378-5955; 1878-5891; 1878-5891
• DOI: 10.1016/j.heares.2021.108176

While electrically-evoked auditory brainstem response (eABR) thresholds for low-rate pulse trains correlate well with behavioral thresholds measured at the same rate, the correlation is much weaker with behavioral thresholds measured at high rates, such as used clinically. This implies that eABRs to low-rate stimuli cannot be reliably used for objective programming of threshold levels in cochlear implant (CI) users. Here, we investigate whether the use of bunched-up pulses (BUPS), consisting of groups of closely-spaced pulses may be used as an alternative stimulus. Experiment 1 measured psychophysical detection thresholds for several stimuli having a period of 32 ms in nine CI subjects implanted with a Med-EL device. The stimuli differed in the number of pulses present in each period (from 1 to 32), the pulse rate within period (1000 pps and as high as possible for BUPS) and the electrode location (apical or basal). The correlation between psychophysical thresholds obtained for a high-rate (1000 pps) clinical stimulus and for the BUPS stimuli increased as the number of pulses per period of BUPS increased from 1 to 32. This first psychophysical experiment suggests that the temporal processes affecting the threshold of clinical stimuli are also present for BUPS. Experiment 2 measured eABRs on the apical electrode of eight CI subjects for BUPS having 1, 2, 4, 8, 16 or 32 pulses per period. For most subjects, wave V was visible for BUPS having up to 16 pulses per period. The latency of wave V at threshold increased as a function of the number of pulses per period, suggesting that the eABR reflects the integration of multiple pulses at such low levels or that the neural response to each individual pulse increases along the sequence due to facilitation processes. There was also a strong within-subject correlation between electrophysiological and behavioral thresholds for the different BUPS stimuli. This demonstrates that the drop in behavioral threshold obtained when increasing the number of pulses per period of the BUPS can be measured electrophysiologically using eABRs. In contrast, the across-subject correlation between eABR thresholds for BUPS and clinical thresholds remained relatively weak and did not increase with the number of pulses per period. Implications of the use of BUPS for objective programming of CIs are discussed.