Translational Control: Selective Upregulation of ECM Components Drives Tumour Growth

A new mechanistic link has been identified between the expression of initiator methionine tRNA and cancer progression, whereby elevated levels of this tRNA specifically drive synthesis of secretome components, resulting in a type II collagen-rich matrix that promotes tumour progression. A new mechan...

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Bibliographic Details
Published inCurrent biology Vol. 26; no. 6; pp. R241 - R243
Main Author Willis, Anne E.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 21.03.2016
Subjects
Humans
Neoplasms
Transcriptional Activation
Up-Regulation
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Summary:A new mechanistic link has been identified between the expression of initiator methionine tRNA and cancer progression, whereby elevated levels of this tRNA specifically drive synthesis of secretome components, resulting in a type II collagen-rich matrix that promotes tumour progression. A new mechanistic link has been identified between the expression of initiator methionine tRNA and cancer progression, whereby elevated levels of this tRNA specifically drive synthesis of secretome components, resulting in a type II collagen-rich matrix that promotes tumour progression.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2016.01.053