Convenient preparation of A-ring fused pyridines from steroidal enamides
A facile strategy for the preparation of A-ring fused pyridosteroids has been accomplished in high yields by the reaction of Vilsmeier reagent (chloromethyleneiminium salt) with steroidal A-ring enamides (2- and 3-ene) under thermal conditions. The structure of 6′-chloro-5α-cholest [3,2- b]pyridine...
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Published in | Steroids Vol. 73; no. 11; pp. 1137 - 1142 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
NEW YORK
Elsevier Inc
01.10.2008
Elsevier Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | A facile strategy for the preparation of A-ring fused pyridosteroids has been accomplished in high yields by the reaction of Vilsmeier reagent (chloromethyleneiminium salt) with steroidal A-ring enamides (2- and 3-ene) under thermal conditions. The structure of 6′-chloro-5α-cholest [3,2-
b]pyridine was determined by X-ray analysis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0039-128X 1878-5867 |
DOI: | 10.1016/j.steroids.2008.04.016 |