Facial nerve outcomes following gamma knife radiosurgery for subtotally resected vestibular schwannomas: Early versus delayed timing of therapy

• Published in: Clinical neurology and neurosurgery Vol. 198; p. 106148
• Main Authors: Ng, Isaac B., Heller, Robert S., Heilman, Carl B., Wu, Julian K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2020; Elsevier Limited
• Subjects: Acoustic neuroma; Brain cancer; Early intervention; Facial nerve; Gamma knife radiosurgery; Hearing loss; Magnetic resonance imaging; Microsurgery; Patients; Radiosurgery; Subtotal resection; Surgery; Surgical outcomes; Tumors; Vestibular schwannoma; Vestibular system; Sweden; Facial nerve; Subtotal resection; Acoustic neuroma; Gamma knife radiosurgery; Vestibular schwannoma
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2020.106148

•Combined STR of large VS with GKRS is a reasonable strategy for preserving facial nerve function.•Gamma knife radiosurgery following STR of VS carries a low risk of facial nerve worsening.•Early and delayed strategies for radiosurgery after STR for VS can both lead to reasonable tumor control rates. Initially treating vestibular schwannomas (VSs) with subtotal resection (STR) followed by Gamma Knife radiosurgery (GKRS) for progression of tumor residual is a strategy that balances maximal tumor resection with preservation of neurological function. The effect of timing of GKRS for residual and recurrent VSs remains poorly defined. We developed a simple and practical treatment algorithm for the timing of GKRS after STR of VSs and reviewed our follow-up results to determine outcomes between patients treated with early vs. late GKRS. Patients that underwent STR between 1999 and 2017 for a VS at Tufts Medical Center were identified and included in the study cohort. Patients who received GKRS ≤ 12 months after STR were included in the early intervention group. Patients who received GKRS > 12 months after STR or did not have tumor progression on follow-up thus not requiring GKRS were included in the observation/delayed intervention group. STR of VSs was performed on 23 patients. Mean patient age at the time of STR was 53.0 years (range: 20–86.2). The mean follow-up was 4.2 years (range: 1 month-15.5 years). Patients most frequently presented with hearing loss. There were 5 patients (21.7 %) in the early intervention group and 18 (78.3 %) patients in the observation/delayed intervention group. Ten of 23 patients (43.5 %) required GKRS. Thirteen (56.5 %) did not receive GKRS. None of the patients in the early intervention group or the observation/delayed intervention group had changes in House-Brackmann (HB) Grade either after GKRS or at the end of the study period. GKRS of residual or recurrent tumor is safe following STR of VS and appears to carry a low risk of worsening facial nerve function when performed for progressive tumor growth.