Peritumoral edema in preoperative magnetic resonance imaging is an independent prognostic factor for hepatocellular carcinoma

• Published in: Clinical imaging Vol. 75; pp. 143 - 149
• Main Authors: He, Hai-Lu, Wang, Qiang, Liu, Lu, Luo, Ning-Bin, Su, Dan-Ke, Jin, Guan-Qiao
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2021; Elsevier Limited
• Subjects: Alanine; Alanine transaminase; Ascites; Aspartate aminotransferase; Biomarkers; Brain cancer; Cirrhosis; Edema; Gender; Hazard assessment; Health hazards; Hepatocellular carcinoma; Laboratories; Liver cancer; Liver cirrhosis; Lymphatic system; Magnetic resonance imaging; Medical imaging; Medical prognosis; Metastasis; Microvasculature; Multivariate analysis; Patients; Peritumoral edema; Permeability; Prognosis; Regression analysis; Resonance; Risk analysis; Risk factors; Statistical analysis; Statistical models; Tumors; Ultrasonic imaging; China; Hepatocellular carcinoma; Prognosis; Peritumoral edema; Magnetic resonance imaging
• ISSN: 0899-7071; 1873-4499
• DOI: 10.1016/j.clinimag.2021.01.022

Peritumoral edema is an independent prognostic risk factor for malignant tumors. Therefore, assessment of peritumoral edema in preoperative magnetic resonance imaging (MRI) may provide better prognostic information in patients with hepatocellular carcinoma (HCC). To determine whether peritumoral edema in preoperative MRI is a prognostic factor for HCC. A retrospective analysis of 90 patients with HCC confirmed by surgical pathology was performed. All patients' peritumoral edema in preoperative MRI was reviewed by two radiologists. The association of disease recurrence with peritumoral edema and clinicopathological features was assessed using the Cox proportional hazards model. Interobserver agreement for evaluating peritumoral edema was determined using Cohen's κ coefficient. Recurrence and non-recurrence after an average 20.8 month follow-up was 25.6% (23/90) and 74.4% (67/90), respectively. The ratio of peritumoral edema of 90 patients with HCC in preoperative MRI was 35.6% (32/90). In univariate Cox regression analysis, peritumoral edema [hazard ratio (HR) 11.08, P < 0.001], tumor diameter (HR 4.12, P = 0.001), microvascular invasion (HR 2.78, P = 0.020), gender (HR 0.29, P = 0.006), cirrhosis (HR 2.45, P = 0.049), ascites syndrome (HR 2.83, P = 0.022), aspartate aminotransferase(AST)/alanine aminotransferase(ALT) (HR 5.07, P = 0.003) were indicators for HCC recurrence. In multivariate Cox regression analysis, the tumor diameter (HR 2.53, P = 0.032) and peritumoral edema (HR 8.71, P < 0.001) were independent prognostic factors of HCC. The sensitivity, specificity, positive predictive value and negative predictive value of peritumoral edema and tumor diameter were 82.6%&60.9%, 80.6%&77.6%, 59.4%&48.3%, and 93.1%&85.3%, respectively. Peritumoral edema in preoperative MRI may be considered as a biomarker of prognostic information for patients with HCC. •The occurrence of peritumoral edema is more progressive and prone to recurrence.•Peritumoral edema is an prognostic factor for hepatocellular carcinoma.•Magnetic resonance imaging can better observation of peritumoral edema.•Can provide prognostic value for patients with hepatocellular carcinoma.