The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells

• Published in: The Journal of immunology (1950) Vol. 206; no. 3; pp. 455 - 462
• Main Authors: Maurice, Nicholas J, Taber, Alexis K, Prlic, Martin
• Format: Journal Article
• Language: English
• Published: United States 01.02.2021
• Subjects: Animals; Bystander Effect - immunology; CD8-Positive T-Lymphocytes - immunology; Humans; Immunity, Heterologous; Immunologic Memory; Infections - immunology; Lymphocyte Activation; Neoplasms - immunology; Vaccines - immunology

Memory T cells (T ) rapidly mount Ag-specific responses during pathogen reencounter. However, T also respond to inflammatory cues in the absence of an activating TCR signal, a phenomenon termed bystander activation. Although bystander activation was first described over 20 years ago, the physiologic...