A hyaluronidase/ATP tandem stimuli-responsive supramolecular assembly

• Published in: Chemical communications (Cambridge, England) Vol. 55; no. 95; pp. 14387 - 1439
• Main Authors: Gao, Jie, Yu, Huijuan, Chen, Fang-Yuan, Hu, Xin-Yue, Wang, Yuefei, Guo, Dong-Sheng
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 26.11.2019
• Subjects: adenosine triphosphate; Adenosine Triphosphate - chemistry; Adenosine Triphosphate - metabolism; aromatic hydrocarbons; Biomarkers; Biomarkers, Tumor - chemistry; Biomarkers, Tumor - metabolism; Calixarenes - chemistry; Calixarenes - metabolism; chemical reactions; Dismantling; eosin; Eosine Yellowish-(YS) - chemistry; Eosine Yellowish-(YS) - metabolism; Guanidine - chemistry; Guanidine - metabolism; Humans; Hyaluronic acid; Hyaluronic Acid - chemistry; Hyaluronic Acid - metabolism; hyaluronoglucosaminidase; Hyaluronoglucosaminidase - chemistry; Hyaluronoglucosaminidase - metabolism; Macromolecular Substances - chemistry; Macromolecular Substances - metabolism; neoplasms; Polymers - chemistry; Polymers - metabolism; Stimuli; Theranostic Nanomedicine; Tumor Microenvironment; Tumors
• ISSN: 1359-7345; 1364-548X; 1364-548X
• DOI: 10.1039/c9cc08199b

We designed a tandem stimuli-responsive assembly based on a guanidinium-modified calix[5]arene (GC5A-6C) and eosin Y modified hyaluronic acid (EY-HA), which showed hyaluronidase-triggered disassembly and ATP-activated release of EY. Both hyaluronidase and ATP are tumor biomarkers, and therefore, the present system shows potential in precision delivery with respect to tumor phototheranostics. We designed a hyaluronidase/ATP tandem stimuli-responsive assembly based on a guanidinium-modified calix[5]arene and eosin Y modified hyaluronic acid.