Anti-inflammatory norabietane diterpenoids from the leaves of Salvia officinalis L

• Published in: Journal of functional foods Vol. 54; pp. 154 - 163
• Main Authors: Li, Lingnan, Wei, Shanshan, Zhu, Tianyu, Xue, Guimin, Xu, Dingqiao, Wang, Wenli, Wang, Xiaobing, Luo, Jianguang, Kong, Lingyi
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.03.2019
• Subjects: anti-inflammatory activity; Bioassay-guided method; C20-norabietane diterpenoids; diterpenoids; drugs; fractionation; herbal tea; leaves; lipopolysaccharides; macrophages; MAPK pathway; mechanism of action; Mediterranean region; Molecular docking; nitric oxide; NO inhibitory effect; sage; Salvia officinalis; spectral analysis; Mediterranean region; MAPK pathway; NO inhibitory effect; Bioassay-guided method; C20-norabietane diterpenoids; Salvia officinalis; Molecular docking

[Display omitted] •Eight new and four known norabietane diterpenoids from S. officinalis were isolated.•7 exhibited the highest NO inhibitory effect in LPS-induced RAW264.7 Cells.•The analysis of structure-activity and effect mechanism by the molecular docking.•The mechanism of action on NO inhibito...