Synthesis and COX Inhibitory Activities of Rutaecarpine Derivatives

A series of substituted rutaecarpines were prepared by employing Fischer indole synthesis as key step and their inhibitory activities on COX-1 and 2 as well as selectivity on COX-2 were evaluated. The compounds with a methanesulfonyl and a bromo group at C10 showed promising inhibitory activity (IC5...

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Published inBulletin of the Korean Chemical Society Vol. 26; no. 12; pp. 1975 - 1980
Main Authors 이응석, Seung Ill Kim, 이승호, 정태천, 문태철, 장현욱, 장영동
Format Journal Article
LanguageEnglish
Published 대한화학회 20.12.2005
Subjects
화학
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Summary:A series of substituted rutaecarpines were prepared by employing Fischer indole synthesis as key step and their inhibitory activities on COX-1 and 2 as well as selectivity on COX-2 were evaluated. The compounds with a methanesulfonyl and a bromo group at C10 showed promising inhibitory activity (IC50 = 0.27, 0.35 M, respectively) with selectivity KCI Citation Count: 14
Bibliography:G704-000067.2005.26.12.017
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2005.26.12.1975