Diverse regulatory mechanisms of StARkin domains in land plants and mammals

The StARkin domain (derived from ‘kin of steroidogenic acute regulatory protein (StAR)’) is an evolutionarily conserved helix-grip-fold structure. StARkin domains possess a deep hydrophobic pocket capable of binding lipophilic ligands such as fatty acids, sterols, and isoprenoids. Dysregulation of S...

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Published inCurrent opinion in plant biology Vol. 64; p. 102148
Main Authors Dresden, Courtney E., Ashraf, Quratulayn, Husbands, Aman Y.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2021
Subjects
Animals
Development
Embryophyta - metabolism
Evolutionary biology
Ligand binding
Ligands
Mammals - metabolism
Protein activity
Regulatory mechanisms
START domain
Sterols - metabolism
START domain
Development
Ligand binding
Evolutionary biology
Protein activity
Regulatory mechanisms
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Summary:The StARkin domain (derived from ‘kin of steroidogenic acute regulatory protein (StAR)’) is an evolutionarily conserved helix-grip-fold structure. StARkin domains possess a deep hydrophobic pocket capable of binding lipophilic ligands such as fatty acids, sterols, and isoprenoids. Dysregulation of StARkin proteins has profound effects on disease and development. In this review, we profile recent mechanistic and evolutionary studies, which highlight the remarkable diversity of regulatory mechanisms employed by the StARkin module. Although primarily focused on land plants, we also discuss select key advances in mammalian StARkin biology. The diversity of perspectives, systems, and approaches described here may be helpful to researchers characterizing poorly understood StARkin proteins.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1369-5266
1879-0356
DOI:10.1016/j.pbi.2021.102148