Cyclical dehydration-induced renal injury and Mesoamerican nephropathy: as sweet by any other name?
Severe cyclical dehydration induces chronic renal injury in rodents. This effect is attenuated by global fructokinase deficiency, suggesting possible roles for fructokinase and fructose metabolism in mediating or promoting dehydration-induced injury. Clinical and pathological similarities between th...
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Published in | Kidney international Vol. 86; no. 2; pp. 226 - 229 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.08.2014
Elsevier Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Severe cyclical dehydration induces chronic renal injury in rodents. This effect is attenuated by global fructokinase deficiency, suggesting possible roles for fructokinase and fructose metabolism in mediating or promoting dehydration-induced injury. Clinical and pathological similarities between this injury model and endemic Mesoamerican nephropathy (MeN) have fueled speculation that dehydration-induced injury and MeN may share common mechanistic underpinnings involving fructokinase that can be targeted to mitigate disease development, progression, and/or severity. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1 |
ISSN: | 0085-2538 1523-1755 |
DOI: | 10.1038/ki.2014.47 |