Expert consensus on management of metabolic disease in Chinese liver transplant recipients

Metabolic disease, including diabetes mellitus, hypertension, dyslipidemia, obesity, and hyperuricemia, is a common complication after liver transplantation and a risk factor for cardiovascular disease and death. The development of metabolic disease is closely related to the side effects of immunosu...

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Published inWorld journal of gastroenterology : WJG Vol. 26; no. 27; pp. 3851 - 3864
Main Authors Shen, Tian, Zhuang, Li, Sun, Xiao-Dong, Qi, Xiao-Sheng, Wang, Zhi-Hui, Li, Rui-Dong, Chang, Wen-Xiu, Yang, Jia-Yin, Yang, Yang, Zheng, Shu-Sen, Xu, Xiao
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 21.07.2020
Subjects
Cardiovascular Diseases
China - epidemiology
Consensus
Diabetes Mellitus
Guidelines
Humans
Hypertension
Immunosuppressive Agents - adverse effects
Liver Transplantation - adverse effects
Metabolic Diseases - etiology
Risk Factors
China
Hypertension
Metabolic disease
Obesity
Hyperuricemia
Diabetes mellitus
Dyslipidemia
Consensus
Immunosuppressive agents
Liver transplantation
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Summary:Metabolic disease, including diabetes mellitus, hypertension, dyslipidemia, obesity, and hyperuricemia, is a common complication after liver transplantation and a risk factor for cardiovascular disease and death. The development of metabolic disease is closely related to the side effects of immunosuppressants. Therefore, optimization of the immunosuppressive regimen is very important for the prevention and treatment of metabolic disease. The Chinese Society of Organ Transplantation has developed an expert consensus on the management of metabolic diseases in Chinese liver transplant recipients based on recent studies. Emphasis is placed on the risk factors of metabolic diseases, the effect of immunosuppressants on metabolic disease, and the prevention and treatment of metabolic diseases.
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Supported by the National Science and Technology Major Project of China, No. 2017ZX10203205; National Natural Science Funds for Distinguished Young Scholar of China, No. 81625003; National Natural Science Foundation of China, No. 81930016.
Author contributions: Shen T designed the primary structure of this consensus with the help of Zhuang L, under the supervision of Zheng SS and Xu X; this paper was mainly written by Zhuang L and Shen T, with the contribution of Sun XD, Qi XS, Wang ZH, Li RD, Chang WX, Yang JY, and Yang Y.
Corresponding author: Xiao Xu, MD, PhD, Chief Doctor, Professor, Surgeon, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79, Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zjxu@zju.edu.cn
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v26.i27.3851