Efficient synthesis of biazoles by aerobic oxidative homocoupling of azoles catalyzed by a copper(i)/2-pyridonate catalytic system

A highly efficient and convenient CuCl/2-pyridonate catalytic system for oxidative homocoupling of azoles affording a biazole product has been developed. With this system, a variety of biazoles have been effectively synthesized in good to excellent yields in the presence of a very small amount of co...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 47; no. 48; pp. 12876 - 12878
Main Authors Zhu, Mingwen, Fujita, Ken-ichi, Yamaguchi, Ryohei
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 28.12.2011
Subjects
Air
Azoles
Azoles - chemical synthesis
Azoles - chemistry
Catalysis
Catalysts
catalytic activity
chemical communication
chemical reactions
Chemistry
Chemistry, Multidisciplinary
Copper
Copper - chemistry
Oxidants
Oxidation-Reduction
Oxidizing agents
Physical Sciences
Pyridones - chemistry
Science & Technology
Synthesis
2,2'-BIIMIDAZOLE
COUPLING REACTIONS
COMPLEXES
ARYLATION
DIMERIZATION
LIGAND
IONIC LIQUIDS
HECK REACTION
DERIVATIVES
HIGHLY EFFICIENT
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Summary:A highly efficient and convenient CuCl/2-pyridonate catalytic system for oxidative homocoupling of azoles affording a biazole product has been developed. With this system, a variety of biazoles have been effectively synthesized in good to excellent yields in the presence of a very small amount of copper catalyst (1.0 mol%). It was feasible to employ air as a green oxidant.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c1cc15363c