Synergy and regulation of antiphage systems: toward the existence of a bacterial immune system?

Bacteria encode a vast repertoire of diverse antiphage defense systems. Recent studies revealed that different defense systems are often encoded within the same genome, raising the question of their possible interactions in a cell. Here, we review the known synergies and coregulations of antiphage s...

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Bibliographic Details
Published inCurrent opinion in microbiology Vol. 71; p. 102238
Main Authors Tesson, Florian, Bernheim, Aude
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2023
Subjects
Animals
Bacteria - genetics
Bacteriophages - genetics
Immune System
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Summary:Bacteria encode a vast repertoire of diverse antiphage defense systems. Recent studies revealed that different defense systems are often encoded within the same genome, raising the question of their possible interactions in a cell. Here, we review the known synergies and coregulations of antiphage systems. The emerging complexities suggest a potential existence of an additional level of organization of antiviral defense in prokaryotes. We argue that this organization could be compared with immune systems of animals and plants. We discuss this concept and explore what it could mean in bacteria. •Different antiphage systems are encoded in one bacterial genome.•Bacterial antiphage systems can function in synergy through different strategies.•Antiphage systems can be co-regulated.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2022.102238