Dominant Stickler Syndrome

• Published in: Genes Vol. 13; no. 6; p. 1089
• Main Authors: Soh, Zack, Richards, Allan J, McNinch, Annie, Alexander, Philip, Martin, Howard, Snead, Martin P
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.06.2022; MDPI
• Subjects: Arthritis; Arthritis - genetics; Birth defects; Cartilage; Cleft lip/palate; COL11A1; COL2A1; Collagen; Congenital diseases; Connective tissue; Connective Tissue Diseases - genetics; Connective Tissue Diseases - pathology; Connective tissues; Craniofacial Abnormalities; Deafness; Eye Diseases, Hereditary; Genes; Genotype & phenotype; giant retinal tear; Haploinsufficiency; Hearing loss; Hearing Loss, Sensorineural; Humans; Marfan syndrome; Osteochondrodysplasias; Pedigree; Phenotypes; Retinal detachment; Retinal Detachment - genetics; Retinal Detachment - pathology; Review; Stickler syndrome; vitreous; giant retinal tear; vitreous; COL2A1; retinal detachment; COL11A1; Stickler syndrome
• ISSN: 2073-4425; 2073-4425
• DOI: 10.3390/genes13061089

The Stickler syndromes are a group of genetic connective tissue disorders associated with an increased risk of rhegmatogenous retinal detachment, deafness, cleft palate, and premature arthritis. This review article focuses on the molecular genetics of the autosomal dominant forms of the disease. Pathogenic variants in causing Stickler syndrome usually result in haploinsufficiency of the protein, whereas pathogenic variants of type XI collagen more usually exert dominant negative effects. The severity of the disease phenotype is thus dependent on the location and nature of the mutation, as well as the normal developmental role of the respective protein.