Improvement of respiratory compromise through abductor reinnervation and pacing in a patient with bilateral vocal fold impairment

• Published in: The Laryngoscope Vol. 120; no. 1; p. 76
• Main Authors: Broniatowski, Michael, Grundfest-Broniatowski, Sharon, Hadley, Aaron J, Shah, Nemath S, Barbu, Anca M, Phillipbar, Sue Ann, Strohl, Kingman P, Tucker, Harvey M, Tyler, Dustin J
• Format: Journal Article
• Language: English
• Published: United States 01.01.2010
• Subjects: Humans; Laryngeal Muscles - innervation; Laryngoscopy; Respiratory Physiological Phenomena; Respiratory Sounds - physiopathology; Spirometry; Synkinesis - physiopathology; Vocal Cord Paralysis - physiopathology; Vocal Cord Paralysis - surgery
• ISSN: 1531-4995
• DOI: 10.1002/lary.20698

To determine whether respiratory compromise from bilateral vocal fold impairment (paralysis) can be objectively alleviated by reinnervation and pacing. A patient with paramedian vocal folds and synkinesis had a tracheotomy for stridor after bilateral laryngeal nerve injury and Miller Fisher syndrome. One posterior cricoarytenoideus (PCA) received a nerve-muscle pedicle fitted with a perineural electrode for pacemaker stimulation. The airway was evaluated endoscopically and by spirometry for up to 1 year. Bilateral vocal fold patency during quiet breathing was reversed to active vocal fold adduction during tracheal occlusion. Peak inspiratory flows (PIFs) were significantly higher (P < .001) after reinnervation. PIFs and glottic apertures increased further under stimulation (42 Hz, 1-4 mA, 42-400 microsec). although the differences were not significant. Based on our preliminary data, PCA reinnervation and pacing offer promise for amelioration of respiratory compromise after paradoxical adduction in bilateral vocal fold impairment.