Progression of Pancreatitis Prior to Diabetes Onset in WBN/Kob-Leprfa Rats

We established the WBN/Kob-Leprfa rat as a new congenic strain for the fa allele of the leptin receptor gene (Lepr). Homozygous (fa/fa) WBN/Kob-Leprfa rats provide a model of non-insulin-dependent diabetes, although its onset is secondary to pancreatitis. In the present study, we compared histopatho...

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Published inJournal of Veterinary Medical Science Vol. 74; no. 1; pp. 65 - 70
Main Authors AKIMOTO, Toshio, TERADA, Misao, SHIMIZU, Akira
Format Journal Article
LanguageEnglish
Published Tokyo JAPANESE SOCIETY OF VETERINARY SCIENCE 01.01.2012
Japan Science and Technology Agency
Subjects
leptin
pancreatitis
WBN/Kob rat
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Summary:We established the WBN/Kob-Leprfa rat as a new congenic strain for the fa allele of the leptin receptor gene (Lepr). Homozygous (fa/fa) WBN/Kob-Leprfa rats provide a model of non-insulin-dependent diabetes, although its onset is secondary to pancreatitis. In the present study, we compared histopathological observations of pancreatitis in each genotype of this rat, to examine its suitability as a model of pancreatitis. The histopathological findings of the pancreatitis revealed intense changes dependent on age, such as hemorrhage or hemosiderin deposition. The pancreatitis in homozygous (fa/fa) WBN/Kob-Leprfa rats were more severe than those of WBN/Kob rats.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.11-0168