Endemic Pemphigus Foliaceus in Venezuela: Report of Two Children

:  Two native Yanomami children from the Venezuelan Amazonia with erythroderma were hospitalized on our service. Clinical, histologic, and immunofluorescence studies diagnosed endemic pemphigus foliaceous. Human leukocyte antigen class II showed DRB1*04 subtype *0411, which has not been previously a...

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Published inPediatric dermatology Vol. 23; no. 2; pp. 132 - 135
Main Authors González, Francisco, Sáenz, Ana Maria, Cirocco, Antonietta, Tacaronte, Inés Maria, Fajardo, Javier Enrique, Calebotta, Adriana
Format Journal Article
LanguageEnglish
Published Malden, USA Blackwell Publishing Inc 01.03.2006
Blackwell
Subjects
Adolescent
Biological and medical sciences
Bullous diseases of the skin
Child
Chloroquine - therapeutic use
Dermatology
Diagnosis, Differential
Female
Humans
Male
Medical sciences
Pemphigus - diagnosis
Pemphigus - drug therapy
Prednisone - therapeutic use
Venezuela
South America
Venezuela
America
Bullous dermatosis
Human
Case study
Pediatrics
Skin disease
Dermatology
Pemphigus foliaceous
Autoimmune disease
Child
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Summary::  Two native Yanomami children from the Venezuelan Amazonia with erythroderma were hospitalized on our service. Clinical, histologic, and immunofluorescence studies diagnosed endemic pemphigus foliaceous. Human leukocyte antigen class II showed DRB1*04 subtype *0411, which has not been previously associated with this disease. However, it shares a common epitope with all the human leukocyte antigen DRB1 alleles that have been involved in this disease among Brazilian populations. Although this condition is endemic in Brazil, our patients are the first two reported in Venezuela.
Bibliography:ObjectType-Case Study-2
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ISSN:0736-8046
1525-1470
DOI:10.1111/j.1525-1470.2006.00197.x