The functional MICA-129 polymorphism is associated with skin but not joint manifestations of psoriatic disease independently of HLA-B and HLA-C
A methionine/valine polymorphism at amino acid 129 of the major histocompatibility complex class I chain‐related gene A (MICA‐129) categorizes alleles into strong and weak binders of the natural killer (NK) and T‐cell receptor NKG2D. We investigated whether MICA‐129 is differentially associated with...
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Published in | Tissue antigens Vol. 82; no. 1; pp. 43 - 47 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.07.2013
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Subjects | |
Online Access | Get full text |
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Summary: | A methionine/valine polymorphism at amino acid 129 of the major histocompatibility complex class I chain‐related gene A (MICA‐129) categorizes alleles into strong and weak binders of the natural killer (NK) and T‐cell receptor NKG2D. We investigated whether MICA‐129 is differentially associated with skin and joint manifestations of psoriatic disease (PsD) independently of human leukocyte antigen (HLA)‐C and HLA‐B in patients and controls from Toronto and St. John's. The MICA‐129 methionine (Met) allele, particularly Met/Met homozygosity, was strongly associated with both cutaneous psoriasis (PsC) and psoriatic arthritis (PsA) independently of HLA‐B and HLA‐C in Toronto patients, and was also associated with PsA in St. John's patients, but with no additional effect of Met/Met homozygosity. No association remained after adjustment for HLA alleles in St. John's patients. MICA‐129 was not associated with PsA when compared with PsC. We conclude that MICA‐129 is a marker of skin manifestations of PsD that is independent of HLA class I in Toronto patients. |
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Bibliography: | istex:C09854F7E0E8C64C4D23454E3BD98EB6646BE04A ArticleID:TAN12126 ark:/67375/WNG-M557MR0H-H ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0001-2815 1399-0039 |
DOI: | 10.1111/tan.12126 |