Histological and analytical studies of a tooth in a patient with cleidocranial dysostosis

• Published in: Journal of Oral Science Vol. 43; no. 2; pp. 85 - 89
• Main Authors: Fukuta, Yohko, Totsuka, Morio, Fukuta, Yoshiyasu, Takeda, Yasunori, Yoshida, Yasuo, Niitsu, Jiro, Yamamoto, Hirotsugu
• Format: Journal Article
• Language: English
• Published: Japan Nihon University School of Dentistry 2001
• Subjects: Bicuspid - abnormalities; Bicuspid - pathology; Calcium - analysis; cellular cementum; cleidocranial dysostosis; Cleidocranial Dysplasia - complications; Dental Cementum - abnormalities; Dental Enamel - chemistry; Dental Enamel Hypoplasia - metabolism; Dental Enamel Hypoplasia - pathology; dentin; Dentin - abnormalities; Dentin - chemistry; Dentistry; Electron Probe Microanalysis; enamel; Female; Humans; Middle Aged; Phosphorus - analysis; Tooth, Impacted - complications; Tooth, Supernumerary - complications; Tooth, Unerupted - complications
• ISSN: 1343-4934; 1880-4926
• DOI: 10.2334/josnusd.43.85

A histopathological and analytical study of a permanent tooth from a patient with cleidocranial dysostosis (CCD) was performed. The patient was a 47-year-old woman, who had 10 erupted permanent teeth and 2 partially erupted and 19 completely impacted teeth, including supernumerary teeth. The erupted right upper premolar was extracted and observed using a light microscope and an electron probe X-ray microanalyzer (EPMA). Findings showed enamel hypoplasia, predominantly irregular globular dentin and Tomes' granular layer, and a complete lack of cellular cementum in the ground section. The incremental von Ebner and counter Owen lines were obscure. Comparative quantitative analysis using the EPMA showed that the quantities of calcium and phosphate were lower in the enamel and dentin than those of the control sample. (J. Oral Sci. 43, 85-89, 2001)