Molecular modelling of HLA-B35:132

Summary Here we describe the molecular modelling of the new variant HLA‐B*35:132. This allele shows one mismatch with B*35:01:01:01 in exon 3 at position 575 where a T is substituted by a C, which implies an amino acidic change from Leucine to Proline. This seems not to alter the molecular structure...

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Bibliographic Details
Published inInternational journal of immunogenetics Vol. 41; no. 3; pp. 195 - 197
Main Authors Longhi, E., Crivello, P., Mantovani, M., Frison, S., Fleischhauer, K., Crespiatico, L., Piccolo, G., Poli, F.
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.06.2014
Subjects
Alleles
Amino Acid Sequence
Base Sequence
Bone Marrow Transplantation
Cloning, Molecular
Exons
Histocompatibility Testing
HLA-B35 Antigen - genetics
HLA-B35 Antigen - immunology
Humans
Models, Molecular
Molecular Sequence Data
Point Mutation
Structural Homology, Protein
Tissue Donors
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Summary:Summary Here we describe the molecular modelling of the new variant HLA‐B*35:132. This allele shows one mismatch with B*35:01:01:01 in exon 3 at position 575 where a T is substituted by a C, which implies an amino acidic change from Leucine to Proline. This seems not to alter the molecular structure and not to compromise the HLA complex and T‐cell receptor interaction.
Bibliography:ark:/67375/WNG-57GXFP0V-0
Telethon Foundation
Cariplo Foundation
istex:24657D323DE8A0721280944CA871BA6A824E1DE1
ArticleID:IJI12105
ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ObjectType-Article-2
ObjectType-Feature-1
ISSN:1744-3121
1744-313X
DOI:10.1111/iji.12105