Clinical and Biochemical Factors Associated With Area and Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT
Context:Body fat distribution and inflammation may play a role in metabolic derangements and cardiovascular disease in obesity.Objective:The aim of this study is to investigate clinical and biochemical factors associated with area and metabolic activity in the visceral and subcutaneous adipose tissu...
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| Published in | The journal of clinical endocrinology and metabolism Vol. 100; no. 5; pp. E739 - E747 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Oxford University Press
01.05.2015
Copyright by The Endocrine Society |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-972X 1945-7197 1945-7197 |
| DOI | 10.1210/jc.2014-3896 |
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| Abstract | Context:Body fat distribution and inflammation may play a role in metabolic derangements and cardiovascular disease in obesity.Objective:The aim of this study is to investigate clinical and biochemical factors associated with area and metabolic activity in the visceral and subcutaneous adipose tissues (VAT and SAT).Participants:
18F-fluorodeoxyglucose-positron emission tomography and computed tomography imaging was performed in 251 consecutive subjects (62.6 ± 9.3 y) for risk screening.Main Outcome Measures:We examined which clinical, anthropometric, metabolic, and inflammatory variables including advanced glycation end products (AGEs) and pigment epithelium-derived factor (PEDF) were independently associated with area and metabolic activity in VAT and SAT. Adipose tissue area was determined with computed tomography, whereas metabolic activity was assessed by 18F-fluorodeoxyglucose uptake expressed as a target to background ratio (TBR) of blood-normalized standardized uptake.Results:Serum levels of AGEs and PEDF were 9.81 ± 3.21 U/mL and 14.0 (range 10.8–17.7) μg/mL, respectively. Although the area in VAT and SAT was associated with waist circumference and sex, each adipose tissue area and TBR had different metabolic risk profiles. The TBR value in VAT was higher than that in SAT. In a multiple stepwise regression analysis, AGEs and medication for hypertension were independently associated with VAT TBR (R2 = 0.102), whereas medication for diabetes, mean intima-media thickness, AGEs, and PEDF were the independent correlates of SAT TBR (R2 = 0.132).Conclusions:The present study demonstrated that area and metabolic activity in VAT and SAT could be differently regulated, suggesting the involvement of AGEs and PEDF in adipose tissue inflammation. |
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| AbstractList | Context:Body fat distribution and inflammation may play a role in metabolic derangements and cardiovascular disease in obesity.Objective:The aim of this study is to investigate clinical and biochemical factors associated with area and metabolic activity in the visceral and subcutaneous adipose tissues (VAT and SAT).Participants: 18F-fluorodeoxyglucose-positron emission tomography and computed tomography imaging was performed in 251 consecutive subjects (62.6 ± 9.3 y) for risk screening.Main Outcome Measures:We examined which clinical, anthropometric, metabolic, and inflammatory variables including advanced glycation end products (AGEs) and pigment epithelium-derived factor (PEDF) were independently associated with area and metabolic activity in VAT and SAT. Adipose tissue area was determined with computed tomography, whereas metabolic activity was assessed by 18F-fluorodeoxyglucose uptake expressed as a target to background ratio (TBR) of blood-normalized standardized uptake.Results:Serum levels of AGEs and PEDF were 9.81 ± 3.21 U/mL and 14.0 (range 10.8–17.7) μg/mL, respectively. Although the area in VAT and SAT was associated with waist circumference and sex, each adipose tissue area and TBR had different metabolic risk profiles. The TBR value in VAT was higher than that in SAT. In a multiple stepwise regression analysis, AGEs and medication for hypertension were independently associated with VAT TBR (R2 = 0.102), whereas medication for diabetes, mean intima-media thickness, AGEs, and PEDF were the independent correlates of SAT TBR (R2 = 0.132).Conclusions:The present study demonstrated that area and metabolic activity in VAT and SAT could be differently regulated, suggesting the involvement of AGEs and PEDF in adipose tissue inflammation. Context:Body fat distribution and inflammation may play a role in metabolic derangements and cardiovascular disease in obesity.Objective:The aim of this study is to investigate clinical and biochemical factors associated with area and metabolic activity in the visceral and subcutaneous adipose tissues (VAT and SAT).Participants: 18F-fluorodeoxyglucose-positron emission tomography and computed tomography imaging was performed in 251 consecutive subjects (62.6 ± 9.3 y) for risk screening.Main Outcome Measures:We examined which clinical, anthropometric, metabolic, and inflammatory variables including advanced glycation end products (AGEs) and pigment epithelium-derived factor (PEDF) were independently associated with area and metabolic activity in VAT and SAT. Adipose tissue area was determined with computed tomography, whereas metabolic activity was assessed by 18F-fluorodeoxyglucose uptake expressed as a target to background ratio (TBR) of blood-normalized standardized uptake.Results:Serum levels of AGEs and PEDF were 9.81 ± 3.21 U/mL and 14.0 (range 10.8–17.7) μg/mL, respectively. Although the area in VAT and SAT was associated with waist circumference and sex, each adipose tissue area and TBR had different metabolic risk profiles. The TBR value in VAT was higher than that in SAT. In a multiple stepwise regression analysis, AGEs and medication for hypertension were independently associated with VAT TBR (R2 = 0.102), whereas medication for diabetes, mean intima-media thickness, AGEs, and PEDF were the independent correlates of SAT TBR (R2 = 0.132).Conclusions:The present study demonstrated that area and metabolic activity in VAT and SAT could be differently regulated, suggesting the involvement of AGEs and PEDF in adipose tissue inflammation. Body fat distribution and inflammation may play a role in metabolic derangements and cardiovascular disease in obesity. The aim of this study is to investigate clinical and biochemical factors associated with area and metabolic activity in the visceral and subcutaneous adipose tissues (VAT and SAT). (18)F-fluorodeoxyglucose-positron emission tomography and computed tomography imaging was performed in 251 consecutive subjects (62.6 ± 9.3 y) for risk screening. We examined which clinical, anthropometric, metabolic, and inflammatory variables including advanced glycation end products (AGEs) and pigment epithelium-derived factor (PEDF) were independently associated with area and metabolic activity in VAT and SAT. Adipose tissue area was determined with computed tomography, whereas metabolic activity was assessed by (18)F-fluorodeoxyglucose uptake expressed as a target to background ratio (TBR) of blood-normalized standardized uptake. Serum levels of AGEs and PEDF were 9.81 ± 3.21 U/mL and 14.0 (range 10.8-17.7) μg/mL, respectively. Although the area in VAT and SAT was associated with waist circumference and sex, each adipose tissue area and TBR had different metabolic risk profiles. The TBR value in VAT was higher than that in SAT. In a multiple stepwise regression analysis, AGEs and medication for hypertension were independently associated with VAT TBR (R(2) = 0.102), whereas medication for diabetes, mean intima-media thickness, AGEs, and PEDF were the independent correlates of SAT TBR (R(2) = 0.132). The present study demonstrated that area and metabolic activity in VAT and SAT could be differently regulated, suggesting the involvement of AGEs and PEDF in adipose tissue inflammation. Body fat distribution and inflammation may play a role in metabolic derangements and cardiovascular disease in obesity.CONTEXTBody fat distribution and inflammation may play a role in metabolic derangements and cardiovascular disease in obesity.The aim of this study is to investigate clinical and biochemical factors associated with area and metabolic activity in the visceral and subcutaneous adipose tissues (VAT and SAT).OBJECTIVEThe aim of this study is to investigate clinical and biochemical factors associated with area and metabolic activity in the visceral and subcutaneous adipose tissues (VAT and SAT).(18)F-fluorodeoxyglucose-positron emission tomography and computed tomography imaging was performed in 251 consecutive subjects (62.6 ± 9.3 y) for risk screening.PARTICIPANTS(18)F-fluorodeoxyglucose-positron emission tomography and computed tomography imaging was performed in 251 consecutive subjects (62.6 ± 9.3 y) for risk screening.We examined which clinical, anthropometric, metabolic, and inflammatory variables including advanced glycation end products (AGEs) and pigment epithelium-derived factor (PEDF) were independently associated with area and metabolic activity in VAT and SAT. Adipose tissue area was determined with computed tomography, whereas metabolic activity was assessed by (18)F-fluorodeoxyglucose uptake expressed as a target to background ratio (TBR) of blood-normalized standardized uptake.MAIN OUTCOME MEASURESWe examined which clinical, anthropometric, metabolic, and inflammatory variables including advanced glycation end products (AGEs) and pigment epithelium-derived factor (PEDF) were independently associated with area and metabolic activity in VAT and SAT. Adipose tissue area was determined with computed tomography, whereas metabolic activity was assessed by (18)F-fluorodeoxyglucose uptake expressed as a target to background ratio (TBR) of blood-normalized standardized uptake.Serum levels of AGEs and PEDF were 9.81 ± 3.21 U/mL and 14.0 (range 10.8-17.7) μg/mL, respectively. Although the area in VAT and SAT was associated with waist circumference and sex, each adipose tissue area and TBR had different metabolic risk profiles. The TBR value in VAT was higher than that in SAT. In a multiple stepwise regression analysis, AGEs and medication for hypertension were independently associated with VAT TBR (R(2) = 0.102), whereas medication for diabetes, mean intima-media thickness, AGEs, and PEDF were the independent correlates of SAT TBR (R(2) = 0.132).RESULTSSerum levels of AGEs and PEDF were 9.81 ± 3.21 U/mL and 14.0 (range 10.8-17.7) μg/mL, respectively. Although the area in VAT and SAT was associated with waist circumference and sex, each adipose tissue area and TBR had different metabolic risk profiles. The TBR value in VAT was higher than that in SAT. In a multiple stepwise regression analysis, AGEs and medication for hypertension were independently associated with VAT TBR (R(2) = 0.102), whereas medication for diabetes, mean intima-media thickness, AGEs, and PEDF were the independent correlates of SAT TBR (R(2) = 0.132).The present study demonstrated that area and metabolic activity in VAT and SAT could be differently regulated, suggesting the involvement of AGEs and PEDF in adipose tissue inflammation.CONCLUSIONSThe present study demonstrated that area and metabolic activity in VAT and SAT could be differently regulated, suggesting the involvement of AGEs and PEDF in adipose tissue inflammation. CONTEXT:Body fat distribution and inflammation may play a role in metabolic derangements and cardiovascular disease in obesity. OBJECTIVE:The aim of this study is to investigate clinical and biochemical factors associated with area and metabolic activity in the visceral and subcutaneous adipose tissues (VAT and SAT). PARTICIPANTS:F-fluorodeoxyglucose-positron emission tomography and computed tomography imaging was performed in 251 consecutive subjects (62.6 ± 9.3 y) for risk screening. MAIN OUTCOME MEASURES:We examined which clinical, anthropometric, metabolic, and inflammatory variables including advanced glycation end products (AGEs) and pigment epithelium-derived factor (PEDF) were independently associated with area and metabolic activity in VAT and SAT. Adipose tissue area was determined with computed tomography, whereas metabolic activity was assessed by F-fluorodeoxyglucose uptake expressed as a target to background ratio (TBR) of blood-normalized standardized uptake. RESULTS:Serum levels of AGEs and PEDF were 9.81 ± 3.21 U/mL and 14.0 (range 10.8–17.7) μg/mL, respectively. Although the area in VAT and SAT was associated with waist circumference and sex, each adipose tissue area and TBR had different metabolic risk profiles. The TBR value in VAT was higher than that in SAT. In a multiple stepwise regression analysis, AGEs and medication for hypertension were independently associated with VAT TBR (R = 0.102), whereas medication for diabetes, mean intima-media thickness, AGEs, and PEDF were the independent correlates of SAT TBR (R = 0.132). CONCLUSIONS:The present study demonstrated that area and metabolic activity in VAT and SAT could be differently regulated, suggesting the involvement of AGEs and PEDF in adipose tissue inflammation. |
| Author | Takeuchi, Masayoshi Fukumoto, Yoshihiro Yamagishi, Sho-ichi Kaida, Hayato Tahara, Nobuhiro Kodama, Norihiro Abe, Toshi Nitta, Yoshikazu Honda, Akihiro Igata, Sachiyo Tahara, Atsuko Kurata, Seiji Matsui, Takanori |
| AuthorAffiliation | Department of Medicine, Division of Cardiovascular Medicine (N.T., N.K., A.T., A.H., Y.N., S.I., Y.F.), and Departments of Radiology (H.K., S.K., T.A.) and Pathophysiology and Therapeutics of Diabetic Vascular Complications (T.M., S.-Y.), Kurume University School of Medicine, Kurume 830-0011, Japan; and Department of Advanced Medicine (M.T.), Medical Research Institute, Kanazawa Medical University, Ishikawa 920-0293, Japan |
| AuthorAffiliation_xml | – name: Department of Medicine, Division of Cardiovascular Medicine (N.T., N.K., A.T., A.H., Y.N., S.I., Y.F.), and Departments of Radiology (H.K., S.K., T.A.) and Pathophysiology and Therapeutics of Diabetic Vascular Complications (T.M., S.-Y.), Kurume University School of Medicine, Kurume 830-0011, Japan; and Department of Advanced Medicine (M.T.), Medical Research Institute, Kanazawa Medical University, Ishikawa 920-0293, Japan |
| Author_xml | – sequence: 1 givenname: Nobuhiro surname: Tahara fullname: Tahara, Nobuhiro email: ntahara@med.kurume-u.ac.jp organization: 1Department of Medicine, Division of Cardiovascular Medicine (N.T., N.K., A.T., A.H., Y.N., S.I., Y.F.), Kurume 830-0011, Japan – sequence: 2 givenname: Sho-ichi surname: Yamagishi fullname: Yamagishi, Sho-ichi organization: 3Pathophysiology and Therapeutics of Diabetic Vascular Complications (T.M., S.-Y.), Kurume University School of Medicine, Kurume 830-0011, Japan – sequence: 3 givenname: Norihiro surname: Kodama fullname: Kodama, Norihiro organization: 1Department of Medicine, Division of Cardiovascular Medicine (N.T., N.K., A.T., A.H., Y.N., S.I., Y.F.), Kurume 830-0011, Japan – sequence: 4 givenname: Atsuko surname: Tahara fullname: Tahara, Atsuko organization: 1Department of Medicine, Division of Cardiovascular Medicine (N.T., N.K., A.T., A.H., Y.N., S.I., Y.F.), Kurume 830-0011, Japan – sequence: 5 givenname: Akihiro surname: Honda fullname: Honda, Akihiro organization: 1Department of Medicine, Division of Cardiovascular Medicine (N.T., N.K., A.T., A.H., Y.N., S.I., Y.F.), Kurume 830-0011, Japan – sequence: 6 givenname: Yoshikazu surname: Nitta fullname: Nitta, Yoshikazu organization: 1Department of Medicine, Division of Cardiovascular Medicine (N.T., N.K., A.T., A.H., Y.N., S.I., Y.F.), Kurume 830-0011, Japan – sequence: 7 givenname: Sachiyo surname: Igata fullname: Igata, Sachiyo organization: 1Department of Medicine, Division of Cardiovascular Medicine (N.T., N.K., A.T., A.H., Y.N., S.I., Y.F.), Kurume 830-0011, Japan – sequence: 8 givenname: Takanori surname: Matsui fullname: Matsui, Takanori organization: 3Pathophysiology and Therapeutics of Diabetic Vascular Complications (T.M., S.-Y.), Kurume University School of Medicine, Kurume 830-0011, Japan – sequence: 9 givenname: Masayoshi surname: Takeuchi fullname: Takeuchi, Masayoshi organization: 4Department of Advanced Medicine (M.T.), Medical Research Institute, Kanazawa Medical University, Ishikawa 920-0293, Japan – sequence: 10 givenname: Hayato surname: Kaida fullname: Kaida, Hayato organization: 2Departments of Radiology (H.K., S.K., T.A.), Kurume 830-0011, Japan – sequence: 11 givenname: Seiji surname: Kurata fullname: Kurata, Seiji organization: 2Departments of Radiology (H.K., S.K., T.A.), Kurume 830-0011, Japan – sequence: 12 givenname: Toshi surname: Abe fullname: Abe, Toshi organization: 2Departments of Radiology (H.K., S.K., T.A.), Kurume 830-0011, Japan – sequence: 13 givenname: Yoshihiro surname: Fukumoto fullname: Fukumoto, Yoshihiro organization: 1Department of Medicine, Division of Cardiovascular Medicine (N.T., N.K., A.T., A.H., Y.N., S.I., Y.F.), Kurume 830-0011, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25695885$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Adipose tissue Adult Advanced glycosylation end products Aged Aged, 80 and over Body fat Body Fat Distribution Cardiovascular diseases Cardiovascular Diseases - diagnostic imaging Cardiovascular Diseases - metabolism Carotid Intima-Media Thickness Computed tomography Diabetes mellitus Epithelium Eye Proteins - blood Female Glycation End Products, Advanced - blood Humans Inflammation Intra-Abdominal Fat - diagnostic imaging Male Metabolic Syndrome - diagnostic imaging Metabolic Syndrome - metabolism Metabolism Middle Aged Nerve Growth Factors - blood Obesity - diagnostic imaging Obesity - metabolism Pigment epithelium-derived factor Positron emission tomography Radiography Radionuclide Imaging Risk Factors Serpins - blood Serum levels Subcutaneous Fat - diagnostic imaging Tomography Waist Circumference |
| Title | Clinical and Biochemical Factors Associated With Area and Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT |
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