Clinical and Biochemical Factors Associated With Area and Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT

• Published in: The journal of clinical endocrinology and metabolism Vol. 100; no. 5; pp. E739 - E747
• Main Authors: Tahara, Nobuhiro, Yamagishi, Sho-ichi, Kodama, Norihiro, Tahara, Atsuko, Honda, Akihiro, Nitta, Yoshikazu, Igata, Sachiyo, Matsui, Takanori, Takeuchi, Masayoshi, Kaida, Hayato, Kurata, Seiji, Abe, Toshi, Fukumoto, Yoshihiro
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2015; Copyright by The Endocrine Society
• Subjects: Adipose tissue; Adult; Advanced glycosylation end products; Aged; Aged, 80 and over; Body fat; Body Fat Distribution; Cardiovascular diseases; Cardiovascular Diseases - diagnostic imaging; Cardiovascular Diseases - metabolism; Carotid Intima-Media Thickness; Computed tomography; Diabetes mellitus; Epithelium; Eye Proteins - blood; Female; Glycation End Products, Advanced - blood; Humans; Inflammation; Intra-Abdominal Fat - diagnostic imaging; Male; Metabolic Syndrome - diagnostic imaging; Metabolic Syndrome - metabolism; Metabolism; Middle Aged; Nerve Growth Factors - blood; Obesity - diagnostic imaging; Obesity - metabolism; Pigment epithelium-derived factor; Positron emission tomography; Radiography; Radionuclide Imaging; Risk Factors; Serpins - blood; Serum levels; Subcutaneous Fat - diagnostic imaging; Tomography; Waist Circumference
• ISSN: 0021-972X; 1945-7197; 1945-7197
• DOI: 10.1210/jc.2014-3896

Context:Body fat distribution and inflammation may play a role in metabolic derangements and cardiovascular disease in obesity.Objective:The aim of this study is to investigate clinical and biochemical factors associated with area and metabolic activity in the visceral and subcutaneous adipose tissues (VAT and SAT).Participants: 18F-fluorodeoxyglucose-positron emission tomography and computed tomography imaging was performed in 251 consecutive subjects (62.6 ± 9.3 y) for risk screening.Main Outcome Measures:We examined which clinical, anthropometric, metabolic, and inflammatory variables including advanced glycation end products (AGEs) and pigment epithelium-derived factor (PEDF) were independently associated with area and metabolic activity in VAT and SAT. Adipose tissue area was determined with computed tomography, whereas metabolic activity was assessed by 18F-fluorodeoxyglucose uptake expressed as a target to background ratio (TBR) of blood-normalized standardized uptake.Results:Serum levels of AGEs and PEDF were 9.81 ± 3.21 U/mL and 14.0 (range 10.8–17.7) μg/mL, respectively. Although the area in VAT and SAT was associated with waist circumference and sex, each adipose tissue area and TBR had different metabolic risk profiles. The TBR value in VAT was higher than that in SAT. In a multiple stepwise regression analysis, AGEs and medication for hypertension were independently associated with VAT TBR (R2 = 0.102), whereas medication for diabetes, mean intima-media thickness, AGEs, and PEDF were the independent correlates of SAT TBR (R2 = 0.132).Conclusions:The present study demonstrated that area and metabolic activity in VAT and SAT could be differently regulated, suggesting the involvement of AGEs and PEDF in adipose tissue inflammation.