Echinogenic action of L-alpha-lysophosphatidylcholine in Duchenne muscular dystrophy: a study on carrier detection

The percentage of echinocytes induced after red cell treatment with L-alpha-lysophosphatidylcholine in the blood of 16 patients affected by Duchenne muscular dystropy (DMD) has been evaluated. Moreover, 15 mothers, 10 sisters, and 15 fathers were also included in the study. We found an increased lev...

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Bibliographic Details
Published inAmerican journal of medical genetics Vol. 32; no. 4; p. 540
Main Authors Tangorra, A, Curatola, G, Milani-Comparetti, M, Ferretti, G
Format Journal Article
LanguageEnglish
Published United States 01.04.1989
Subjects
Adolescent
Adult
Child
Creatine Kinase - blood
Erythrocyte Membrane - drug effects
Erythrocyte Membrane - pathology
Female
Fructose-Bisphosphate Aldolase - blood
Genetic Carrier Screening
Humans
L-Lactate Dehydrogenase - blood
Lysophosphatidylcholines - pharmacology
Male
Middle Aged
Muscular Dystrophies - blood
Muscular Dystrophies - diagnosis
Muscular Dystrophies - genetics
Pedigree
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Summary:The percentage of echinocytes induced after red cell treatment with L-alpha-lysophosphatidylcholine in the blood of 16 patients affected by Duchenne muscular dystropy (DMD) has been evaluated. Moreover, 15 mothers, 10 sisters, and 15 fathers were also included in the study. We found an increased level of echinocytes in dystrophic patients and in known and possible carriers. Correlations were also evaluated between echinocytes and serum enzymes used in DMD diagnosis, showing an increase of echinocytes also in DMD carriers with normal levels of serum creatine kinase, lactate dehydrogenase, and aldolase. Our results suggest that the sensitivity of erythrocytes to L-alpha-lysophosphatidylcholine in DMD could be used as a diagnostic test for carrier detection.
ISSN:0148-7299
DOI:10.1002/ajmg.1320320423