β-Cyclodextrin⁻Hyaluronic Acid Polymer Functionalized Magnetic Graphene Oxide Nanocomposites for Targeted Photo-Chemotherapy of Tumor Cells

• Published in: Polymers Vol. 11; no. 1; p. 133
• Main Authors: Liang, Wenting, Huang, Yu, Lu, Dongtao, Ma, Xuewen, Gong, Tao, Cui, Xiaodong, Yu, Baofeng, Yang, Cheng, Dong, Chuan, Shuang, Shaomin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.01.2019; MDPI
• Subjects: Biocompatibility; Cancer therapies; Chemotherapy; Cyclodextrins; Doxorubicin; Drug delivery systems; Ethanol; Fourier transforms; Graphene; Graphite; Hyaluronic acid; Infrared heating; Iron oxides; magnetic graphene oxide; Magnetic separation; Nanocomposites; Nanomaterials; Nanoparticles; Near infrared radiation; near-infrared; photo-chemotherapy; Polymers; Quantum dots; Spectrum analysis; β-cyclodextrin; United States > US; China; magnetic graphene oxide; near-infrared; β-cyclodextrin; hyaluronic acid; photo-chemotherapy
• ISSN: 2073-4360; 2073-4360
• DOI: 10.3390/polym11010133

A multifunctional targeted drug delivery platform (CDHA⁻MGO) has been successfully constructed by grafting β-cyclodextrin⁻hyaluronic acid polymers (CDHA) to Fe₃O₄⁻graphene oxide (MGO). The obtained CDHA⁻MGO nanocomposite has good water-dispersibility, easy magnetic separation, high near-infrared (NIR) photothermal heating, and excellent biocompatibility. The β-cyclodextrin-hyaluronic acid polymers efficaciously enhance the doxorubicin (DOX) loading amount up to 485.43 mg·g . Meanwhile, the Fe₃O₄⁻graphene oxide provides a facile photothermal response mechanism to handle the NIR-triggered release of DOX in weak acidic solvent environments. Significantly, the DOX-loaded nanocomposite (DOX@CDHA⁻MGO) has displayed CD44 receptor-mediated active targeting recognition and chemo-photothermal synergistic therapy of hepatoma cells. These findings suggest that the as-prepared drug delivery platform would be of valuable potential for cancer-targeted photo-chemotherapy.