Oral vaccines: new needs, new possibilities

• Published in: BioEssays Vol. 29; no. 6; pp. 591 - 604
• Main Authors: Aziz, Mohd Azhar, Midha, Shuchi, Waheed, Syed Mohsin, Bhatnagar, Rakesh
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2007
• Subjects: Administration, Oral; Communicable Diseases - immunology; Developing Countries; Global Health; Health Services Needs and Demand; Humans; Immunity, Mucosal - physiology; Immunization Programs; Vaccination - economics; Vaccines - administration & dosage; Vaccines - economics; Vaccines - immunology
• ISSN: 0265-9247; 1521-1878
• DOI: 10.1002/bies.20580

Vaccination is an important tool for handling healthcare programs both in developed and developing countries. The current global scenario calls for a more‐efficacious, acceptable, cost‐effective and reliable method of immunization for many fatal diseases. It is hoped that the adoption of oral vaccines will help to provide an effective vaccination strategy, especially in developing countries. Mucosal immunity generated by oral vaccines can serve as a strong first line of defense against most of the pathogens infecting through the mucosal lining. Advances in elucidating the mechanism of action of oral vaccines will facilitate the design of more effective, new generation vaccines. There are promising developments in the use of different agents to effectively deliver the vaccine candidate. It is hoped that ongoing research may be able to set another cardinal point, after polio vaccine, in eradicating infectious diseases. BioEssays 29:591–604, 2007. © 2007 Wiley Periodicals, Inc.