Evaluation of an orally administered vaccine, using hydrogels containing bacterial exotoxins of Pasteurella haemolytica, in cattle

• Published in: American journal of veterinary research Vol. 55; no. 4; p. 502
• Main Authors: Bowersock, T.L, Shalaby, W.S.W, Levy, M, Samuels, M.L, Lallone, R, White, M.R, Borie, D.L, Lehmeyer, J, Park, K
• Format: Journal Article
• Language: English
• Published: United States 01.04.1994
• Subjects: Administration, Oral; Animals; Antibodies, Bacterial - biosynthesis; Antibodies, Bacterial - immunology; Antigens, Bacterial - immunology; Bacterial Vaccines - administration & dosage; Bacterial Vaccines - immunology; BACTERIOSE; BACTERIOSIS; Cattle; Cattle Diseases - immunology; Cattle Diseases - microbiology; Cattle Diseases - prevention & control; COLLOIDE; COLOIDES; CONTROL DE ENFERMEDADES; CONTROLE DE MALADIES; CULTIVO DE CELULAS; CULTURE DE CELLULE; Culture Media, Conditioned; Enzyme-Linked Immunosorbent Assay; Hydrogel, Polyethylene Glycol Dimethacrylate; Immunoblotting; Mannheimia haemolytica - immunology; METHODE D'APPLICATION; METODOS DE APLICACION; PASTEURELLA; Pasteurella Infections - microbiology; Pasteurella Infections - prevention & control; Pasteurella Infections - veterinary; Polyethylene Glycols; TERNERO; TOXINAS; TOXINE; VACCIN; VACUNA; VEAU

Poly(methacrylic acid) hydrogels were tested for oral delivery of a vaccine against Pasteurella haemolytica infection in cattle. Culture supernatants of P haemolytica, the most common bacterium associated with pneumonia in cattle, were used as the antigens in the vaccine. Hydrogels containing cultur...