Evaluation of an orally administered vaccine, using hydrogels containing bacterial exotoxins of Pasteurella haemolytica, in cattle

Poly(methacrylic acid) hydrogels were tested for oral delivery of a vaccine against Pasteurella haemolytica infection in cattle. Culture supernatants of P haemolytica, the most common bacterium associated with pneumonia in cattle, were used as the antigens in the vaccine. Hydrogels containing cultur...

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Bibliographic Details
Published inAmerican journal of veterinary research Vol. 55; no. 4; p. 502
Main Authors Bowersock, T.L, Shalaby, W.S.W, Levy, M, Samuels, M.L, Lallone, R, White, M.R, Borie, D.L, Lehmeyer, J, Park, K
Format Journal Article
LanguageEnglish
Published United States 01.04.1994
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Summary:Poly(methacrylic acid) hydrogels were tested for oral delivery of a vaccine against Pasteurella haemolytica infection in cattle. Culture supernatants of P haemolytica, the most common bacterium associated with pneumonia in cattle, were used as the antigens in the vaccine. Hydrogels containing culture supernatants were administered orally to calves. Calves were then challenge-exposed with virulent P haemolytica. Calves were euthanatized 3 days after challenge exposure. The lungs of each calf were scored for severity and size of pneumonic lesions. Results indicated that vaccinated calves had smaller, less severe pneumonic lesions and lived longer than nonvaccinated calves. These results indicated that hydrogels can be used to deliver vaccines orally to calves to enhance resistance to pneumonia caused by P haemolytica
Bibliography:9452548
L73
ISSN:0002-9645
1943-5681
DOI:10.2460/ajvr.1994.55.04.502