Engineered Bacterial Cellulose Nanostructured Matrix for Incubation and Release of Drug-Loaded Oil in Water Nanoemulsion

Bacterial cellulose (BC) is a highly pure form of cellulose produced by bacteria, which possesses numerous advantages such as good mechanical properties, high chemical flexibility, and the ability to assemble in nanostructures. Thanks to these features, it achieved a key role in the biomedical field...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in bioengineering and biotechnology Vol. 10; p. 851893
Main Authors Di Natale, Concetta, De Gregorio, Vincenza, Lagreca, Elena, Mauro, Francesca, Corrado, Brunella, Vecchione, Raffaele, Netti, Paolo Antonio
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 09.03.2022
Subjects
antioxidant
bacterial cellulose
Bioengineering and Biotechnology
drug delivery
nanocellulose network
nanoemulsion
nanocellulose network
antioxidant
drug delivery
nanoemulsion
bacterial cellulose
Online AccessGet full text

Cover

More Information
Summary:Bacterial cellulose (BC) is a highly pure form of cellulose produced by bacteria, which possesses numerous advantages such as good mechanical properties, high chemical flexibility, and the ability to assemble in nanostructures. Thanks to these features, it achieved a key role in the biomedical field and in drug delivery applications. BC showed its ability to modulate the release of several drugs and biomolecules to the skin, thus improving their clinical outcomes. This work displays the loading of a 3D BC nanonetwork with an innovative drug delivery nanoemulsion system. BC was optimized by static culture of SCOBY (symbiotic colony of bacteria and yeast) and characterized by morphological and ultrastructural analyses, which indicate a cellulose fiber diameter range of 30-50 nm. BC layers were then incubated at different time points with a nanocarrier based on a secondary nanoemulsion (SNE) previously loaded with a well-known antioxidant and anti-inflammatory agent, namely, coenzyme-Q10 (Co-Q10). Incubation of Co-Q10-SNE in the BC nanonetwork and its release were analyzed by fluorescence spectroscopy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Angelina Angelova, UMR8612 Institut Galien Paris Sud (IGPS), France
This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology
Reviewed by: Qing Qing, Changzhou University, China
Edited by: Xiubo Zhao, The University of Sheffield, United Kingdom
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2022.851893