Systemic infection of Leishmania tropica (major) in various strains of mice

The spleen cells of different strains of mice were cultured and examined for the presence of viable promastigotes one to three months following a cutaneous inoculation of 1 to 2 × 10 6 promastigotes of Leishmania tropica (major). The spleen cultures of all five strains tested (BALB/c, DBA/2, C3H, CB...

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Published inTransactions of the Royal Society of Tropical Medicine and Hygiene Vol. 75; no. 6; pp. 851 - 854
Main Authors Leclerc, C., Modabber, F., Deriaud, E., Cheddid, L.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 1981
Royal Society of Tropical Medicine and Hygiene
Subjects
Animals
Female
Leishmaniasis - immunology
Leishmaniasis - parasitology
Male
Mice
Mice, Inbred Strains
Spleen - parasitology
Time Factors
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Summary:The spleen cells of different strains of mice were cultured and examined for the presence of viable promastigotes one to three months following a cutaneous inoculation of 1 to 2 × 10 6 promastigotes of Leishmania tropica (major). The spleen cultures of all five strains tested (BALB/c, DBA/2, C3H, CBA and C57B1/6) contained organisms. Viable parasites were present in the spleen of resistant strains (C3H, CBA, C57B1/6) even after recovery from their cutaneous lesion. The possible implication of this finding in the long lasting immunity observed in this disease is discussed.
Bibliography:istex:11167EDBDC8F49D77AE01CAA80E082D72BCBF528
Address for correspondence and reprints.
ark:/67375/HXZ-30KXC2LN-P
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0035-9203
1878-3503
DOI:10.1016/0035-9203(81)90430-2