The development of subretinal microphotodiodes for replacement of degenerated photoreceptors

There are presently several concepts to restore vision in blind or highly visually handicapped persons by implanting electronic devices into the eye in order to partially restore vision. Here, the approach to replace retinal photoreceptors by a subretinally implanted microphotodiode array (MPDA) is...

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Bibliographic Details
Published inOphthalmic research Vol. 29; no. 5; p. 269
Main Authors Zrenner, E, Miliczek, K D, Gabel, V P, Graf, H G, Guenther, E, Haemmerle, H, Hoefflinger, B, Kohler, K, Nisch, W, Schubert, M, Stett, A, Weiss, S
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1997
Subjects
Animals
Biocompatible Materials
Electroretinography
Eye, Artificial
Humans
Microelectrodes
Photoreceptor Cells - physiopathology
Prostheses and Implants
Prosthesis Implantation
Rabbits
Rats
Retinal Degeneration - physiopathology
Retinal Degeneration - rehabilitation
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Summary:There are presently several concepts to restore vision in blind or highly visually handicapped persons by implanting electronic devices into the eye in order to partially restore vision. Here, the approach to replace retinal photoreceptors by a subretinally implanted microphotodiode array (MPDA) is summarized. A survey is given on the present state of the development of MPDAs, the possibility of in vitro and in vivo tests as well as first results on biocompatibility and histology. Additionally, electrophysiological recordings in rabbits and rats are presented which have received such subretinal implants.
ISSN:0030-3747
1423-0259
DOI:10.1159/000268025