Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats

• Published in: The American journal of physiology Vol. 266; no. 3 Pt 1; p. E459
• Main Authors: Barragán, J M, Rodríguez, R E, Blázquez, E
• Format: Journal Article
• Language: English
• Published: United States 01.03.1994
• Subjects: Animals; Blood Pressure - drug effects; Catecholamines - antagonists & inhibitors; Glucagon - pharmacology; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Heart Rate - drug effects; Male; Peptide Fragments - pharmacology; Peptides - pharmacology; Rats; Rats, Sprague-Dawley; Reserpine - pharmacology
• ISSN: 0002-9513
• DOI: 10.1152/ajpendo.1994.266.3.e459

This study was designed to determine the effects of glucagon-like peptides (GLP) on arterial blood pressure and heart rate. Although glucagon caused a minimal effect and GLP-1-(1-37) produced a moderate increase of both systolic and diastolic blood pressure, GLP-1-(7-36) amide induced the greatest increases in both parameters. Systolic and diastolic blood pressure and heart rate values increased when doses of the peptides were increased. By contrast, GLP-2 did not modify either arterial blood pressure or heart rate values. To determine whether the effects of GLP-1-(7-36) amide were mediated through catecholamines, the rats were pretreated with reserpine, propranolol, or phentolamine before administration of the peptide. In these three experimental groups, GLP-1-(7-36) amide increases mean arterial blood pressure and heart rate to the same level or even greater than that observed in nonpretreated rats. These findings indicate that GLP-1-(7-36) amide significantly increases arterial blood pressure and heart rate and that these effects are not mediated through catecholamines.