In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems

• Published in: Expert opinion on drug delivery Vol. 17; no. 1; p. 33
• Main Authors: Pinto, Soraia, Pintado, Manuela E, Sarmento, Bruno
• Format: Journal Article
• Language: English
• Published: England 02.01.2020
• Subjects: Administration, Buccal; Animals; Drug Delivery Systems; Humans; Mouth Mucosa - metabolism; Permeability; Pharmaceutical Preparations - administration & dosage; Pharmacokinetics; Oral cavity; drug delivery systems; animal models; ex vivo studies; permeability studies
• ISSN: 1744-7593
• DOI: 10.1080/17425247.2020.1699913

: Buccal mucosa has been described as an attractive site for local and systemic drug delivery, owing its accessibility, safety, and excellent blood supply. The absorption of drugs through buccal mucosa has been assessed by and permeability studies, using animal and cell-based models with close resemblance to the human buccal mucosa. : This paper focuses on the current and permeability studies to analyze the absorption of compounds of interest through buccal mucosa, as well as their advantages and limitations in the preclinical studies of the drugs absorption profiles. The techniques for preparation and preservation of the animal buccal tissue are also discussed to evaluate their interference in the integrity and permeability of the tissues. : Overall, the permeability studies have been useful to evaluate the drugs absorption and to clarify the mechanism of transport of drugs across human buccal mucosa, as well as to explain the enhancement of permeability provided by certain dosage forms. Currently, several researchers have demonstrated particular interest in permeability studies, due to their effectiveness in the evaluation of drug absorption and low costs in the acquisition of buccal mucosa samples.