Male breast cancer in the hereditary nonpolyposis colorectal cancer syndrome
A male member of a large HNPCC kindred, affected by primary malignancies of the breast and colon, was identified. This individual was found to harbor a germline mutation of the MLH1 mismatch repair gene previously shown to segregate with disease in this kindred. The breast tumor exhibited somatic re...
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Published in | Breast cancer research and treatment Vol. 53; no. 1; pp. 87 - 91 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Dordrecht
Springer
1999
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | A male member of a large HNPCC kindred, affected by primary malignancies of the breast and colon, was identified. This individual was found to harbor a germline mutation of the MLH1 mismatch repair gene previously shown to segregate with disease in this kindred. The breast tumor exhibited somatic reduction to homozygosity for the MLH1 mutation, and microsatellite instability was evident in the breast tumor. We conclude that hereditary male breast cancer can occur as an integral tumor in the HNPCC syndrome. |
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Bibliography: | ObjectType-Case Study-3 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-2 |
ISSN: | 0167-6806 1573-7217 |
DOI: | 10.1023/A:1006030116357 |