Early postoperative pulmonary complications after minimally invasive esophagectomy in the prone position: incidence and perioperative risk factors from the perspective of anesthetic management

• Published in: General thoracic and cardiovascular surgery Vol. 70; no. 7; pp. 659 - 667
• Main Authors: Ishikawa, Seiji, Ozato, Shojiro, Ebina, Toshiaki, Yoshioka, Sayaka, Miichi, Mitsuhisa, Watanabe, Masayuki, Yokota, Miyuki
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.07.2022; Springer Nature B.V
• Subjects: Anesthesia; Carbon dioxide; Cardiac Surgery; Cardiology; Chronic obstructive pulmonary disease; Cohort analysis; Epidural; Esophageal cancer; Hospitals; Intensive care; Medical laboratories; Medical personnel; Medicine; Medicine & Public Health; Mortality; Original Article; Ostomy; Patients; Pneumonia; Pneumothorax; Postoperative period; Pulmonary embolisms; Respiratory failure; Risk factors; Surgeons; Surgery; Surgical Oncology; Thoracic Surgery; Ventilators; One-lung ventilation; Prone position; Postoperative pulmonary complication; Minimally invasive esophagectomy; Risk factors
• ISSN: 1863-6705; 1863-6713
• DOI: 10.1007/s11748-022-01818-2

Objectives To investigate the incidence of and the risk factors for early postoperative pulmonary complications (PPC) after minimally invasive esophagectomy (MIE) in the prone position from the perspective of anesthetic management. Methods We conducted a historical cohort study of patients who underwent MIE in the prone position between September 2010 and August 2018. PPC was defined as pneumonia, atelectasis, acute respiratory distress syndrome (ARDS), respiratory failure, and pulmonary embolism (Clavien–Dindo Classification Grade II or higher) that occurred within 7 days after MIE. Results Out of 489 patients, there were 90 patients (18.4%) with PPC: 75 patients with pneumonia, 24 patients with atelectasis, 13 patients with respiratory failure, 6 patients with ARDS, and 2 patients with pulmonary embolism. Twenty-eight patients suffered from 2 or more components of PPC. PPC patients were older (66.6 vs. 63.6 year, P  = 0.038) and had higher amount of crystalloid (4200 vs. 3550 mL, P  < 0.0001), and longer duration of anesthesia (670 vs. 625 min, P  = 0.0062) than non-PPC patients. PPC patients were more likely to have had chronic obstructive pulmonary disease (COPD) (26.7 vs. 7.8%, P  < 0.001). Incidence of PPC was significantly higher in patients with one-lung ventilation than with two-lung ventilation (37.1 vs. 15.3%, P  < 0.001). Multivariable logistic regression analysis showed that PPC was associated with age (per 10 years, odds ratio (OR) = 1.41), COPD (OR = 3.43), one-lung ventilation (OR = 1.94), and volume of crystalloid (per 500 mL, OR = 1.22). Conclusions Two-lung rather than one-lung ventilation should be chosen and fluid overload should be avoided in patients undergoing MIE in the prone position.