Agarofuran sesquiterpenes from Schaefferia argentinensis

• Published in: Phytochemistry (Oxford) Vol. 94; pp. 260 - 267
• Main Authors: García, Manuela E., Motrich, Rubén D., Caputto, Beatriz L., Sánchez, Marianela, Palermo, Jorge A., Estévez-Braun, Ana, Ravelo, Angel G., Nicotra, Viviana E.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.10.2013; Elsevier
• Subjects: aerial parts; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Antiproliferative activity; Biochemistry & Molecular Biology; Celastraceae; Celastraceae - chemistry; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Dihydro-β-agarofuran sesquiterpene; Humans; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Mass Spectrometry - methods; MCF-7 Cells; Molecular Structure; nuclear magnetic resonance spectroscopy; Phytochemistry; Plant Components, Aerial - chemistry; Plant Sciences; Schaefferia argentinensis; Science & Technology; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; sesquiterpenoids; Dihydro-β-agarofuran sesquiterpene; Antiproliferative activity; Phytochemistry; Schaefferia argentinensis; Celastraceae; ASSAY; CYTOTOXIC DIHYDROAGAROFURANOID SESQUITERPENES; MAYTENUS-CANARIENSIS; Dihydro-beta-agarofuran sesquiterpene; BIOLOGICAL-ACTIVITY; ESTERS; CHEMISTRY
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2013.06.003

Sixteen dihydro-β-agarofuran sesquiterpenes were isolated from the aerial parts of Schaefferia argentinensis. The in vitro antiproliferative activity of the major sesquiterpenes was examined against T47D, MCF7, and MDA human cancer cell lines. The activity observed for the tested compounds is marginal. •Schaefferia is one of the least studied genera in the Celastraceae family.•Sixteen dihydro-β-agarofuran sesquiterpenes were isolated from S. argentinensis.•The in vitro antiproliferative activity of the major sesquiterpenes was evaluated. Sixteen dihydro-β-agarofuran sesquiterpenes were isolated from the aerial parts of Schaefferia argentinensis Speg. Their structures were determined by a combination of 1D and 2D NMR and MS techniques. The in vitro antiproliferative activity of the major sesquiterpenes was examined in T47D, MCF7, and MDA-MB231 human cancer cell lines, but was found to be marginal.