Lipid Metabolic Process Involved in Oocyte Maturation During Folliculogenesis

Oocyte maturation is a complex and dynamic process regulated by the coordination of ovarian cells and numerous extraovarian signals. From mammal studies, it is learnt that lipid metabolism provides sufficient energy for morphological and cellular events during folliculogenesis, and numerous lipid me...

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Published inFrontiers in cell and developmental biology Vol. 10; p. 806890
Main Authors Liu, Tao, Qu, Jiangxue, Tian, Mengyuan, Yang, Rui, Song, Xueling, Li, Rong, Yan, Jie, Qiao, Jie
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 31.03.2022
Subjects
Cell and Developmental Biology
cholesterol
folliculogenesis
lipid metabolism
lipoprotein
meiotic resumption
β-oxidation
meiotic resumption
β-oxidation
folliculogenesis
cholesterol
lipoprotein
lipid metabolism
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Summary:Oocyte maturation is a complex and dynamic process regulated by the coordination of ovarian cells and numerous extraovarian signals. From mammal studies, it is learnt that lipid metabolism provides sufficient energy for morphological and cellular events during folliculogenesis, and numerous lipid metabolites, including cholesterol, lipoproteins, and 14-demethyl-14-dehydrolanosterol, act as steroid hormone precursors and meiotic resumption regulators. Endogenous and exogenous signals, such as gonadotropins, insulin, and cortisol, are the upstream regulators in follicular lipid metabolic homeostasis, forming a complex and dynamic network in which the key factor or pathway that plays the central role is still a mystery. Though lipid metabolites are indispensable, long-term exposure to a high-fat environment will induce irreversible damage to follicular cells and oocyte meiosis. This review specifically describes the transcriptional expression patterns of several lipid metabolism–related genes in human oocytes and granulosa cells during folliculogenesis, illustrating the spatiotemporal lipid metabolic changes in follicles and the role of lipid metabolism in female reproductive capacity. This study aims to elaborate the impact of lipid metabolism on folliculogenesis, thus providing guidance for improving the fertility of obese women and the clinical outcome of assisted reproduction.
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Reviewed by: You-Qiang Su, Nanjing Medical University, China
This article was submitted to Molecular and Cellular Reproduction, a section of the journal Frontiers in Cell and Developmental Biology
Lucie Němcová, Academy of Sciences of the Czech Republic (ASCR), Czechia
Edited by: Zhao-Jia Ge, Qingdao Agricultural University, China
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.806890