National and international initiatives and approaches for the establishment of reference intervals in pediatric laboratory medicine

Thoroughly validated laboratory medicine reference intervals for children of all ages groups have been published increasingly during the last years. The aim of this review is to present a number of these studies and the various approaches to the generation of reference intervals. Population-based da...

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Bibliographic Details
Published inLaboratoriumsmedizin Vol. 39; no. 4; pp. 197 - 212
Main Author Kohse, Klaus P.
Format Journal Article
LanguageEnglish
Published De Gruyter 01.07.2015
Subjects
age dependence
Altersabhängigkeit
Frühgeburten
Neugeborene
newborn
pediatric laboratory medicine
preterm neonates
pädiatrische Laboratoriumsmedizin
reference intervals
Referenzintervalle
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Summary:Thoroughly validated laboratory medicine reference intervals for children of all ages groups have been published increasingly during the last years. The aim of this review is to present a number of these studies and the various approaches to the generation of reference intervals. Population-based data obtained in large cohorts of healthy children in Germany, Northern Europe, North America, and selected other countries as well as patient-derived data collected in many areas of the world are discussed. Additionally, special research aspects such as reference intervals for preterm neonates, preanalytical issues, intraindividual variation of analytes, or follow-up studies that are covered in many of these studies are presented.
ISSN:0342-3026
1439-0477
DOI:10.1515/labmed-2015-0055