4,4′-Methylenedianiline-induced hepatitis in an industrial worker: Case report and review of the literature

• Published in: Human & experimental toxicology Vol. 30; no. 7; pp. 762 - 767
• Main Authors: Giouleme, Olga, Karabatsou, Sofia, Hytiroglou, Prodromos, Xanthis, Andreas, Tsiaousi, Eleni, Katsaros, Marios, Koliouskas, Dimitrios
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.2011; Sage Publications Ltd
• Subjects: Acute Disease; Adult; Allergens - toxicity; Aniline Compounds - toxicity; Chemical and Drug Induced Liver Injury - drug therapy; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - pathology; Human exposure; Humans; Liver; Liver - drug effects; Liver - pathology; Liver Function Tests; Male; Methylprednisolone - therapeutic use; Occupational accidents; Occupational Diseases - drug therapy; Occupational Diseases - etiology; Occupational Diseases - pathology; Toxicology; Treatment Outcome; methylene-dianiline; hepatotoxicity; toxic hepatitis
• ISSN: 0960-3271; 1477-0903
• DOI: 10.1177/0960327110376549

4,4′-Methylenedianiline (MDA) is a chemical used in manufacturing and insulation processes and is a well-known hepatotoxin. We report the case of a 42-year-old construction-site worker who was accidentally exposed to large amounts of MDA and developed acute liver damage. The clinical course is described, with particular emphasis on the timely identification of the underlying cause and prompt management that led to an uneventful recovery. We review the relevant literature and discuss the safety measures necessary to minimize similar occupational hazards in industrial workers.