Advancement of single-cell sequencing for clinical diagnosis and treatment of pancreatic cancer

Single-cell sequencing is a high-throughput technique that enables detection of genomic, transcriptomic, and epigenomic information at the individual cell level, offering significant advantages in detecting cellular heterogeneity, precise cell classification, and identifying rare subpopulations. The...

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Published inFrontiers in medicine Vol. 10; p. 1213136
Main Authors Zhang, Ke, Chen, Yuan, Zhu, Jie, Ge, Xinyu, Wu, Junqing, Xu, Peng, Yao, Jie
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 31.08.2023
Subjects
heterogeneity
Medicine
microenvironment
pancreatic cancer
personalized therapy
single-cell sequencing
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Summary:Single-cell sequencing is a high-throughput technique that enables detection of genomic, transcriptomic, and epigenomic information at the individual cell level, offering significant advantages in detecting cellular heterogeneity, precise cell classification, and identifying rare subpopulations. The technique holds tremendous potential in improving the diagnosis and treatment of pancreatic cancer. Moreover, single-cell sequencing provides unique insights into the mechanisms of pancreatic cancer metastasis and cachexia, paving the way for developing novel preventive strategies. Overall, single-cell sequencing has immense potential in promoting early diagnosis, guiding personalized treatment, and preventing complications of pancreatic cancer. Emerging single-cell sequencing technologies will undoubtedly enhance our understanding of the complex biology of pancreatic cancer and pave the way for new directions in its clinical diagnosis and treatment.
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These authors have contributed equally to this work and share first authorship
Edited by: Laila A. Damiati, University of Jeddah, Saudi Arabia
Reviewed by: Peter Natesan Pushparaj, King Abdulaziz University, Saudi Arabia; Marwa El Soury, University of Turin, Italy
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2023.1213136