Organelle communication: Signaling crossroads between homeostasis and disease

• Published in: The international journal of biochemistry & cell biology Vol. 50; pp. 55 - 59
• Main Authors: Bravo-Sagua, Roberto, Torrealba, Natalia, Paredes, Felipe, Morales, Pablo E., Pennanen, Christian, López-Crisosto, Camila, Troncoso, Rodrigo, Criollo, Alfredo, Chiong, Mario, Hill, Joseph A., Simmen, Thomas, Quest, Andrew F., Lavandero, Sergio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.05.2014
• Subjects: Alzheimer's disease; Biochemistry; Biology; Calcium signaling; Calcium Signaling - physiology; Cellular; Endoplasmic reticulum; Homeostasis; Humans; Hypertension; Lipid Metabolism; Lipids; Mitochondria; Mitochondria - metabolism; Organelles; Organelles - metabolism; Organelles - pathology; Signal Transduction; Calcium signaling; PtSer; MCUR1; NCX; JNK; InsP3; Drp1; Mitochondria; FFAT; InsP3R; OSBP; BNIP1; Mfn1; SOCE; Mfn2; IGF-1R; IGF-1; Organelles; CMT2A; ER; OMM; ERAD; PACS2; Ca2; Δψmt; NE; MAM; PH; VDAC1; CERT; MPTP; MICU1; Endoplasmic reticulum; Grp75; PM; MCU
• ISSN: 1357-2725; 1878-5875
• DOI: 10.1016/j.biocel.2014.01.019

Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are important for Ca2+ and lipid homeostasis, and serve as platforms for the control of many essential functions including metabolism, signaling, organelle integrity and execution of the apoptotic program. Emerging evidence also highlights the importance of organelle communication in disorders such as Alzheimer's disease, pulmonary arterial hypertension, cancer, skeletal and cardiac muscle dysfunction. Here, we provide an overview of the current literature on organelle communication and the link to human pathologies.