Laryngeal tuberculosis in renal allograft patients

• Published in: American journal of kidney diseases Vol. 31; no. 4; p. 701
• Main Authors: Tato, A M, Pascual, J, Orofino, L, Fernández-Juárez, G, Martínez-San-Millán, J, Fogué, L, Liaño, F, Ortuño, J
• Format: Journal Article
• Language: English
• Published: United States 01.04.1998
• Subjects: Adult; Antitubercular Agents - administration & dosage; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Kidney Transplantation; Middle Aged; Postoperative Complications - diagnosis; Postoperative Complications - drug therapy; Postoperative Complications - immunology; Time Factors; Transplantation, Homologous; Tuberculosis, Laryngeal - diagnosis; Tuberculosis, Laryngeal - drug therapy; Tuberculosis, Laryngeal - immunology
• ISSN: 1523-6838
• DOI: 10.1053/ajkd.1998.v31.pm9580143

Laryngeal tuberculosis, although the most common granulomatous disease of the larynx, is a rare form of extrapulmonary tuberculosis, never reported in immunosuppressed allograft recipients. We present two cases of laryngeal tuberculosis in renal transplant patients and a review of the literature. Two women, a 29-year-old and a 60-year-old, each more than 9 years after their cadaveric renal allograft, presented with a 2-week febrile illness with hoarseness and dysphagia, and both were found to have laryngeal tuberculosis by direct laryngoscopy. Although both radiographs were unremarkable, both patients had sputum positive for acid-fast bacilli that subsequently grew Mycobacterium tuberculosis. Clinical response promptly followed institution of isoniazid, rifampicin, and pyrazinamide in each case, although both required threefold increases in daily cyclosporin A dosage to maintain therapeutic levels.