Ciprofloxacin overdose: acute renal failure with prominent apoptotic changes

• Published in: American journal of kidney diseases Vol. 31; no. 4; p. 710
• Main Authors: Dharnidharka, V R, Nadeau, K, Cannon, C L, Harris, H W, Rosen, S
• Format: Journal Article
• Language: English
• Published: United States 01.04.1998
• Subjects: Acute Kidney Injury - chemically induced; Acute Kidney Injury - pathology; Adolescent; Anti-Infective Agents - adverse effects; Antidepressive Agents, Second-Generation - adverse effects; Apoptosis - drug effects; Biopsy; Ciprofloxacin - adverse effects; Drug Overdose - pathology; Female; Humans; Kidney - drug effects; Kidney - ultrastructure; Trazodone - adverse effects

Acute renal failure due to ciprofloxacin has been well described. The previously reported cases have been consistent both clinically and pathologically with tubulointerstitial nephritis (TIN). We report a case of ciprofloxacin overdose leading to acute renal failure characterized by acute tubular ne...