Ciprofloxacin overdose: acute renal failure with prominent apoptotic changes

Acute renal failure due to ciprofloxacin has been well described. The previously reported cases have been consistent both clinically and pathologically with tubulointerstitial nephritis (TIN). We report a case of ciprofloxacin overdose leading to acute renal failure characterized by acute tubular ne...

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Bibliographic Details
Published inAmerican journal of kidney diseases Vol. 31; no. 4; p. 710
Main Authors Dharnidharka, V R, Nadeau, K, Cannon, C L, Harris, H W, Rosen, S
Format Journal Article
LanguageEnglish
Published United States 01.04.1998
Subjects
Acute Kidney Injury - chemically induced
Acute Kidney Injury - pathology
Adolescent
Anti-Infective Agents - adverse effects
Antidepressive Agents, Second-Generation - adverse effects
Apoptosis - drug effects
Biopsy
Ciprofloxacin - adverse effects
Drug Overdose - pathology
Female
Humans
Kidney - drug effects
Kidney - ultrastructure
Trazodone - adverse effects
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Summary:Acute renal failure due to ciprofloxacin has been well described. The previously reported cases have been consistent both clinically and pathologically with tubulointerstitial nephritis (TIN). We report a case of ciprofloxacin overdose leading to acute renal failure characterized by acute tubular necrosis (ATN). The outstanding features in the patient's renal biopsy were those of distal nephron apoptosis, best seen in plastic-embedded sections and electron microscopy. This report shows that the distal nephron can be singularly involved in acute renal failure and that electron microscopy or plastic-embedded sections may be necessary to define its involvement.
ISSN:1523-6838
DOI:10.1053/ajkd.1998.v31.pm9531191