Chagas' Disease in Patients with Kidney Transplants: 7 Years of Experience, 1989–1996
Chagas' disease was present in 17.22% of persons undergoing kidney transplantation in an Argentine Hospital. The criterion for attributing reactivation of chronic Chagas' disease and transmission of Trypanosoma cruzi to grafts was detection of parasites in blood (patent parasitemia) or tis...
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Published in | Clinical infectious diseases Vol. 29; no. 3; pp. 561 - 567 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Chicago, IL
The University of Chicago Press
01.09.1999
University of Chicago Press |
Subjects | |
Online Access | Get full text |
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Summary: | Chagas' disease was present in 17.22% of persons undergoing kidney transplantation in an Argentine Hospital. The criterion for attributing reactivation of chronic Chagas' disease and transmission of Trypanosoma cruzi to grafts was detection of parasites in blood (patent parasitemia) or tissues. Reactivation was diagnosed in 5 (21.7%) of 23 recipients. Ten (43.4%) of 23 chagasic recipients without reactivation of chronic Chagas' disease had abrogation of serological reactivity. T. cruzi infection was transmitted to 3 (18.7%) of 16 non-chagasic recipients. Reactivation and infection were diagnosed by patent parasitemia or cutaneous panniculitis. For diagnosis, detection of parasites in blood and tissues had more relevance than serology. Sequential monitoring detected early reactivation and infection, permitting application of preemptive or therapeutic therapy with benznidazole, thus inhibiting, in all patients, severe clinical disease produced by a progressive and systemic replication of the parasite. |
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Bibliography: | ark:/67375/HXZ-0QVSHXW6-Q istex:7E907945EA6C5394261204D5664D929568E17DEF ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1058-4838 1537-6591 |
DOI: | 10.1086/598634 |