Dynamic changes in CD45RA− Foxp3high regulatory T-cells in chronic hepatitis C patients during antiviral therapy

Highlights • Activated regulatory T-cells (aTreg cells) were found to express high levels of CD39, CD73, and transforming growth factor beta (TGF-β). • Total Treg cells and aTreg cells decreased during antiviral therapy. • Targeting aTreg might be a future solution to prevent relapse of chronic hepa...

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Published inInternational journal of infectious diseases Vol. 45; no. C; pp. 5 - 12
Main Authors Li, Zhiqin, Ping, Yu, Yu, Zujiang, Wang, Meng, Yue, Dongli, Zhang, Zhen, Li, Jianbin, Zhang, Bin, Shi, Xuezhong, Zhang, Yi
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.04.2016
Elsevier
Subjects
HCV antiviral therapy
IFN-α
Infectious Disease
Pulmonary/Respiratory
Ribavirin
Treg cells
IFN-α
Treg cells
HCV antiviral therapy
Ribavirin
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Abstract Highlights • Activated regulatory T-cells (aTreg cells) were found to express high levels of CD39, CD73, and transforming growth factor beta (TGF-β). • Total Treg cells and aTreg cells decreased during antiviral therapy. • Targeting aTreg might be a future solution to prevent relapse of chronic hepatitis C.
AbstractList Highlights • Activated regulatory T-cells (aTreg cells) were found to express high levels of CD39, CD73, and transforming growth factor beta (TGF-β). • Total Treg cells and aTreg cells decreased during antiviral therapy. • Targeting aTreg might be a future solution to prevent relapse of chronic hepatitis C.
Objectives: CD4+Foxp3+ regulatory T-cells (Treg) are known to accumulate under certain pathological conditions. This study was conducted to evaluate the characteristics of and dynamic changes in Treg cells in chronic hepatitis C (CHC) patients during antiviral therapy. Methods: One hundred and forty-five subjects were enrolled in this study, including 105 CHC patients and 40 healthy donors. The phenotypes and functions of Treg cells were analyzed by flow cytometry. Results: A significant elevation in Treg cells was observed in the peripheral blood of CHC patients compared with healthy donors. Interestingly, compared with non-suppressive Treg (non-Treg) and resting Treg (rTreg) cells, activated Treg (aTreg) cells expressed higher levels of ectonucleotidase, CD39, and CD73. After treatment with interferon alpha (IFN-α) and ribavirin (RBV) in vitro, the frequencies of total Treg cells and aTreg cells in peripheral blood mononuclear cells (PBMC), as well as the levels of transforming growth factor beta (TGF-β) secreted by aTreg and non-Treg cells, were significantly decreased. Importantly, it was found that levels of aTreg cells in patients with a sustained virological response (SVR) were lower than in relapsed patients, suggesting that a high frequency of aTreg cells might be associated with a poor clinical outcome in HCV infection. Conclusion: These results demonstrate a decreasing trend in aTreg cells, which express higher levels of CD39, CD73, and TGF-β, in SVR patients during antiviral therapy.
•Activated regulatory T-cells (aTreg cells) were found to express high levels of CD39, CD73, and transforming growth factor beta (TGF-β).•Total Treg cells and aTreg cells decreased during antiviral therapy.•Targeting aTreg might be a future solution to prevent relapse of chronic hepatitis C. CD4+Foxp3+ regulatory T-cells (Treg) are known to accumulate under certain pathological conditions. This study was conducted to evaluate the characteristics of and dynamic changes in Treg cells in chronic hepatitis C (CHC) patients during antiviral therapy. One hundred and forty-five subjects were enrolled in this study, including 105 CHC patients and 40 healthy donors. The phenotypes and functions of Treg cells were analyzed by flow cytometry. A significant elevation in Treg cells was observed in the peripheral blood of CHC patients compared with healthy donors. Interestingly, compared with non-suppressive Treg (non-Treg) and resting Treg (rTreg) cells, activated Treg (aTreg) cells expressed higher levels of ectonucleotidase, CD39, and CD73. After treatment with interferon alpha (IFN-α) and ribavirin (RBV) in vitro, the frequencies of total Treg cells and aTreg cells in peripheral blood mononuclear cells (PBMC), as well as the levels of transforming growth factor beta (TGF-β) secreted by aTreg and non-Treg cells, were significantly decreased. Importantly, it was found that levels of aTreg cells in patients with a sustained virological response (SVR) were lower than in relapsed patients, suggesting that a high frequency of aTreg cells might be associated with a poor clinical outcome in HCV infection. These results demonstrate a decreasing trend in aTreg cells, which express higher levels of CD39, CD73, and TGF-β, in SVR patients during antiviral therapy.
Author Ping, Yu
Li, Zhiqin
Zhang, Zhen
Yue, Dongli
Shi, Xuezhong
Yu, Zujiang
Zhang, Bin
Zhang, Yi
Wang, Meng
Li, Jianbin
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SSID ssj0004668
Score 2.2081637
Snippet Highlights • Activated regulatory T-cells (aTreg cells) were found to express high levels of CD39, CD73, and transforming growth factor beta (TGF-β). • Total...
•Activated regulatory T-cells (aTreg cells) were found to express high levels of CD39, CD73, and transforming growth factor beta (TGF-β).•Total Treg cells and...
Objectives: CD4+Foxp3+ regulatory T-cells (Treg) are known to accumulate under certain pathological conditions. This study was conducted to evaluate the...
SourceID doaj
crossref
elsevier
SourceType Open Website
Aggregation Database
Publisher
StartPage 5
SubjectTerms HCV antiviral therapy
IFN-α
Infectious Disease
Pulmonary/Respiratory
Ribavirin
Treg cells
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Title Dynamic changes in CD45RA− Foxp3high regulatory T-cells in chronic hepatitis C patients during antiviral therapy
URI https://www.clinicalkey.es/playcontent/1-s2.0-S1201971216000266
https://dx.doi.org/10.1016/j.ijid.2016.02.006
https://doaj.org/article/c90f4d2e12ca4474be76d96584f1e52f
Volume 45
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