Dynamic changes in CD45RA− Foxp3high regulatory T-cells in chronic hepatitis C patients during antiviral therapy

Highlights • Activated regulatory T-cells (aTreg cells) were found to express high levels of CD39, CD73, and transforming growth factor beta (TGF-β). • Total Treg cells and aTreg cells decreased during antiviral therapy. • Targeting aTreg might be a future solution to prevent relapse of chronic hepa...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of infectious diseases Vol. 45; no. C; pp. 5 - 12
Main Authors Li, Zhiqin, Ping, Yu, Yu, Zujiang, Wang, Meng, Yue, Dongli, Zhang, Zhen, Li, Jianbin, Zhang, Bin, Shi, Xuezhong, Zhang, Yi
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.04.2016
Elsevier
Subjects
HCV antiviral therapy
IFN-α
Infectious Disease
Pulmonary/Respiratory
Ribavirin
Treg cells
IFN-α
Treg cells
HCV antiviral therapy
Ribavirin
Online AccessGet full text

Cover

More Information
Summary:Highlights • Activated regulatory T-cells (aTreg cells) were found to express high levels of CD39, CD73, and transforming growth factor beta (TGF-β). • Total Treg cells and aTreg cells decreased during antiviral therapy. • Targeting aTreg might be a future solution to prevent relapse of chronic hepatitis C.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2016.02.006