Periodontitis and Systemic Inflammation : Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers

• Published in: Journal of dental research Vol. 83; no. 2; pp. 156 - 160
• Main Authors: D’Aiuto, F., Parkar, M., Andreou, G., Suvan, J., Brett, P.M., Ready, D., Tonetti, M.S.
• Format: Journal Article
• Language: English
• Published: United States SAGE Publications 01.02.2004; SAGE PUBLICATIONS, INC
• Subjects: Aggregatibacter actinomycetemcomitans - isolation & purification; atherosclerosis; Bacteroides - isolation & purification; Biomarkers - blood; C-reactive protein; C-Reactive Protein - analysis; Confidence Intervals; Confounding Factors (Epidemiology); Female; Follow-Up Studies; Humans; infection; inflammation; Inflammation - prevention & control; Inflammation Mediators - blood; Interleukin-6 - blood; Longitudinal Studies; Male; Middle Aged; Periodontal Pocket - microbiology; Periodontal Pocket - therapy; periodontitis; Periodontitis - blood; Periodontitis - microbiology; Periodontitis - prevention & control; Pilot Projects; Porphyromonas gingivalis - isolation & purification; Prospective Studies; Single-Blind Method; atherosclerosis; infection; C-reactive protein; inflammation; periodontitis
• ISSN: 0022-0345; 1544-0591
• DOI: 10.1177/154405910408300214

Severe periodontitis is associated with elevated inflammatory markers in otherwise healthy populations. However, the nature of this association has not been determined. Our aim was to assess whether the degree of response to periodontal therapy was associated with changes in serological markers of systemic inflammation. Ninety-four systemically healthy subjects with severe generalized periodontitis participated in a prospective six-month blind intervention trial. Periodontal parameters and inflammatory markers [C-reactive Protein (CRP) and Interleukin-6 (IL-6)] were evaluated prior to and 2 and 6 mos after delivery of standard non-surgical periodontal therapy. Six months after treatment, significant reductions in serum IL-6 (p < 0.001, median decrease 0.2 ng/L, 95% CI 0.1–0.4 ng/L) and CRP (p < 0.0001, median decrease 0.5 mg/L, 95% CI 0.4–0.7) were observed. Decreases in inflammatory markers were significant in subjects with above average clinical response to periodontal therapy after correction for possible confounders. Periodontitis may add to the systemic inflammatory burden of affected individuals.