Motor Imagery and Paired Associative Stimulation in Poststroke Rehabilitation: Dissociating Motor and Electrophysiological Effects

• Published in: Applied sciences Vol. 13; no. 10; p. 6063
• Main Authors: Brihmat, Nabila, Castel-Lacanal, Evelyne, Tarri, Mohamed, Lepage, Benoit, Montane, Emmeline, Cormier, Camile, de Boissezon, Xavier, Gasq, David, Loubinoux, Isabelle, Marque, Philippe
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 15.05.2023; Multidisciplinary digital publishing institute (MDPI)
• Subjects: corticospinal excitability; Imagery; Intervention; kinematics; Life Sciences; Mental task performance; Motor evoked potentials; motor function; motor imagery; Neural plasticity; PAS; Rehabilitation; Stimulation; Stroke; Synergistic effect; Transcranial magnetic stimulation; Wrist; wrist extension recovery; France; United Kingdom; corticospinal excitability; wrist extension; motor imagery; kinematics; Paired associative simulation; motor function; Motor recovery
• ISSN: 2076-3417; 2076-3417
• DOI: 10.3390/app13106063

Paired associative stimulation (PAS) is an intervention that modulates cortical plasticity. Motor imagery (MI) is used in the rehabilitation of stroke patients. We aimed to evaluate the possible synergistic effect of associating both interventions for potentiating motor recovery poststroke. MIPAS is a single-center, randomized controlled trial that enrolled 24 hemiparetic poststroke participants. Three single-session interventions were tested in a crossover design: PAS/MI, PAS, and ShamPAS/MI during which the affected Extensor Carpi Radialis (ECR) muscle was targeted. During MI, the participants were instructed to imagine extending their paretic wrist. We used Sham, subthreshold stimulation during ShamPAS. Changes in ECR Motor-Evoked Potential (MEP) areas and paretic wrist Range of Motion (aROM) during active extension were compared between the interventions. We observed no significant superior effect of any intervention, neither on MEP nor on wrist aROM. A time of assessment effect was highlighted for both outcome measures, with MEP- and aROM-measured post-interventions significantly higher than those measured pre-intervention. Despite the beneficial effect of each intervention on participant paretic wrist motor function, not always associated with MEP change, our results do not highlight a specific advantage in combining PAS and MI interventions in post-stroke motor rehabilitation.