Some statistical properties of estimates of no-effect concentrations

No-effect concentrations (NECs) for toxicants are of interest from a biological and a legislation point of view. Using artificial, but typical, examples of the results of a bioassay on survival and two different models for the concentration-effect relationship, we show that the likelihood based conf...

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Bibliographic Details
Published inWater research (Oxford) Vol. 30; no. 7; pp. 1724 - 1728
Main Authors Kooijman, S.A.L.M., Bedaux, J.J.M.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 1996
Elsevier Science
Subjects
Animal, plant and microbial ecology
Applied ecology
bioassays
Biological and medical sciences
Ecotoxicology, biological effects of pollution
Fundamental and applied biological sciences. Psychology
hazard model
log-logistic model
NEC
profile likelihood
survival
Techniques
bioassays
profile likelihood
NEC
log-logistic model
hazard model
survival
Pollutant
Statistical analysis
Test
Poison
Models
Concentration
Survival
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Summary:No-effect concentrations (NECs) for toxicants are of interest from a biological and a legislation point of view. Using artificial, but typical, examples of the results of a bioassay on survival and two different models for the concentration-effect relationship, we show that the likelihood based confidence set of the NEC as parameter of the hazard model has quite acceptable statistical properties. Contrary to the hazard model, the NEC of the standard log-logistic model did not differ significantly from zero.
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ISSN:0043-1354
1879-2448
DOI:10.1016/0043-1354(96)00055-3